206552-17-2Relevant academic research and scientific papers
The discovery of anthranilic acid-based MMP inhibitors. Part 3: Incorporation of basic amines
Levin,Chen,Du,Nelson,Wehr,DiJoseph,Killar,Skala,Sung,Sharr,Roth,Jin,Cowling,Di,Sherman,Xu,March,Mohler,Black,Skotnicki
, p. 2975 - 2978 (2007/10/03)
Anthranilic acid derivatives bearing basic amines were prepared and evaluated in vitro and in vivo as inhibitors of MMP-1, MMP-9, MMP-13, and TACE. Piperazine 4u has been identified as a potent, selective, orally active inhibitor of MMP-9 and MMP-13.
