206552-86-5

Usage

Uses

Used in Pharmaceutical Industry:
2'-O-Propylguanosine is used as a therapeutic agent for the development of RNA-based drugs, targeting specific RNA molecules to treat various diseases and conditions.
Used in Biomedical Research:
2'-O-Propylguanosine is used as a research tool for studying the structure and function of RNA molecules, enabling scientists to gain insights into the role of specific nucleotides in RNA function and their interactions with other molecules.
Used in Drug Delivery Systems:
2'-O-Propylguanosine can be used in the development of drug delivery systems, potentially improving the delivery, bioavailability, and therapeutic outcomes of RNA-based drugs.

Upstream product

• 188658-54-0 6-O-(tert-Butyldiphenylsilyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine 
• 118-00-3 G 
• 69304-44-5 3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine 
• 197151-23-8 6-(tert-Butyl-diphenyl-silanyloxy)-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-prop-2-ynyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-ylamine 

Relevant academic research and scientific papers

Metal free, click and click-click conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase

A fast and practical metal free conjugation of ribonucleosides and 2′-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3′- or the 5′-terminus of the oligoribonucleotide substrate.

Protection of the guanine residue during synthesis of 2'-O-alkyl-guanosine derivatives

Highly selective 2'-O-alkylation of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine has been achieved by using an alkyl halide and a sterically hindered strong organic base, when the 6-O atom is protected with either a 2-nitrophenyl or a tert-butyldiphenylsilyl group prior to the alkylation.A minimum of chromatography is required, the yields are high and none of the unwanted isomer is produced.Moreover, the highly versatile intermediates enable the synthesis of several new 2'-O-alkylguanosine derivatives as well as base-modified analogues.