206555-77-3Relevant articles and documents
2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas
Shibasaki, Kaho,Togo, Hideo
, p. 2520 - 2527 (2019/04/04)
Treatment of alkylarenes with N-bromosuccinimide in a mixture of ethyl acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of diethyl carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino- 4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, respectively, in one pot. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions.
4 - substituted -2 - amino thiazole compound preparation method
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Paragraph 0024; 0025; 0026; 0027; 0028; 0029-0044; 0075-0079, (2017/08/24)
The invention discloses a preparation method of a 4-substituted-2-aminothiazole compound. The method comprises the following step: olefin azide shown by the formula I reacts with potassium thiocyanate under the catalysis of palladium acetate to obtain the 4-substituted-2-aminothiazole compound, wherein the molar ratio of the olefin azide compound to potassium thiocyanate to palladium acetate is 20:(59-61):1, the reaction temperature is 75-85 DEG C, and the reaction time is 11-13 hours; and in the formula I, R1 is phenyl, 2-bromophenyl, 3-bromophenyl, 4-bromophenyl, 4-methylphenyl, 4-ethyoxy-3-bromophenyl, 3-nitrophenyl, 4-methoxyacylphenyl, 1-naphthyl, phenylaminomethyl or trans-4-(3-phenylallyloxymethyl).
Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA
Annadurai, Sivakumar,Martinez, Rogelio,Canney, Daniel J.,Eidem, Tess,Dunman, Paul M.,Abou-Gharbia, Magid
supporting information, p. 7719 - 7725 (2013/02/21)
Privileged structure-based libraries have been shown to provide high affinity lead compounds for a variety of important biological targets. The present study describes the synthesis and screening of a 2-aminothiazole based compound library to determine th