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(S)‐2‐(3‐benzoylthioureido)propanoic acid is a chiral aroylthiourea ligand derived from L-alanine, characterized by its benzoylthiourea moiety attached to the amino acid backbone. It has been used in the synthesis of water-soluble Ru(II)–p-cymene complexes for asymmetric transfer hydrogenation of ketones, demonstrating high catalytic efficiency and enantioselectivity. (S)‐2‐(3‐benzoylthioureido)propanoic acid has also been studied in co-crystal formations and as a derivative of benzoyl isothiocyanate, with structural confirmation via spectroscopy, XRD, and computational analysis. Its carboxylic acid group is notably unreactive, limiting its cyclization potential in certain synthetic pathways.

206557-10-0

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206557-10-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 206557-10-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,6,5,5 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 206557-10:
(8*2)+(7*0)+(6*6)+(5*5)+(4*5)+(3*7)+(2*1)+(1*0)=120
120 % 10 = 0
So 206557-10-0 is a valid CAS Registry Number.

206557-10-0Relevant articles and documents

Water soluble Ru (II)–p-cymene complexes of chiral aroylthiourea ligands derived from unprotected D/L-alanine as proficient catalysts for asymmetric transfer hydrogenation of ketones

Sheeba, Mani Mary,Tamizh, Manoharan Muthu,Bhuvanesh, Nattamai S.P.,Karvembu, Ramasamy

, (2019)

The newfangled chiral aroylthiourea ligands (L1-L6) were produced from unprotected D/L-alanine and their water soluble Ru (II) organometallic catalysts (1–6) were designed from their reaction with [RuCl2(η6-p-cymene)]2. The analytical and spectral methods were used to confirm the structure of the ligands and complexes. The solid state structure of L1, 5 and 6 was confirmed by single crystal XRD. The organometallic compounds (1–6) catalyzed the asymmetric transfer hydrogenation of aromatic, heteroaromatic and bulky ketones to yield respective enantiopure secondary alcohols with admirable conversions (up to 99%) and attractive enantiomeric excesses (ee up to 98%), in presence of formic acid and triethylamine in water medium under non-inert atmospheric conditions.

Characterization of some amino acid derivatives of benzoyl isothiocyanate: Crystal structures and theoretical prediction of their reactivity

Odame, Felix,Hosten, Eric C.,Betz, Richard,Lobb, Kevin,Tshentu, Zenixole R.

, p. 38 - 48 (2015)

The reaction of benzoyl isothiocyanate with l-serine, l-proline, d-methionine and l-alanine gave 2-[(benzoylcarbamothioyl)amino]-3-hydroxypropanoic acid (I), 1-(benzoylcarbamothioyl)pyrrolidine-2-carboxylic acid (II), 2-[(benzoylcarbamothioyl)amino]-4-(methylsulfanyl)butanoic acid (III) and 2-[(benzoylcarbamothioyl)amino]propanoic acid (IV), respectively. The compounds have been characterized by IR, NMR, microanalyses and mass spectrometry. The crystal structures of all the compounds have also been discussed. Compound II showed rotamers in solution. DFT calculations of the frontier orbitals of the compounds have been carried out to ascertain the groups that contribute to the HOMO and LUMO, and to study their contribution to the reactivity of these compounds. The calculations indicated that the carboxylic acid group in these compounds is unreactive hence making the conversion to benzimidazoles via cyclization on the carboxylic acids impractical. This has been further confirmed by the reaction of compounds I-IV, respectively, with o-phenylene diamine which was unsuccessful but gave compound V.

Characterization and Computational Studies of a co-Crystal of 2-Aminobenzimidazole and 2-[(Benzoylcarbamothioyl)Amino]Propanoic Acid

Odame,Hosten,Betz,Lobb,Tshentu

, p. 1200 - 1204 (2018/12/10)

A novel co-crystal of 2-aminobenzimidazole and 2-[(benzoylcarbamothioyl)amino] propanoic acid is synthesized and characterized by spectroscopy, elemental analysis, GC-MS, and single crystal XRD. A computation of the structures involved in the formation of

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