2066-88-8

Basic information

• Product Name: NSC 407340
• Synonyms: 2,6-Dioxo-4-piperidineacetaldehyde;3-(ForMylMethyl)glutariMide;NSC 407340;4-Piperidineacetaldehyde, 2,6-dioxo-
• CAS NO: 2066-88-8
• Molecular Formula: C₇H₉NO₃
• Molecular Weight: 155.15126
• Product Categories: Heterocycles, Intermediates
• Mol File: 2066-88-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 122-123 °C(Solv: acetone (67-64-1); hexane (110-54-3))
• Boiling Point: 369.3°Cat760mmHg
• Flash Point: 181.2°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.467
• PKA: 11.42±0.40(Predicted)
• CAS DataBase Reference: NSC 407340(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 407340(2066-88-8)
• EPA Substance Registry System: NSC 407340(2066-88-8)

Safety Data

• Hazardous Substances Data: 2066-88-8(Hazardous Substances Data)

Usage

Uses

3-(Formylmethyl)glutarimide is a glutaramide derivative used in the preparation of antiviral agents.

InChI:InChI=1/C7H9NO3/c9-2-1-5-3-6(10)8-7(11)4-5/h2,5H,1,3-4H2,(H,8,10,11)

Upstream product

• 772-50-9 (2,6-dioxo-piperidin-4-yl)-acetyl chloride 
• 6258-28-2 (2,6-dioxopiperidin-4-yl)acetic acid 
• 1149347-46-5 3-[(dodecylthio-carbonyl)-methyl]-glutarimide 

Downstream Products

• 15885-91-3 4-[4-(2,6-dioxo-piperidin-4-ylmethyl)-6-(4-nitro-phenyl)-2-piperidin-1-yl-3,4-dihydro-2H-pyran-3-yl]-piperidine-2,6-dione 
• 94130-63-9 (2S,4S,6R,αS)-cycloheximide 
• 66-81-9 (2S,4S,6S,αS)-cycloheximide 
• 642-81-9 Cycloheximide 
• 66-81-9 Cycloheximide 
• 6746-42-5 (+)-(2R,4S,6R,αR)-Isocycloheximide 
• 18006-33-2 (-)-α-Epiisocycloheximide 
• 131077-81-1 4-[2-((3S,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-81-1 4-[2-((3R,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 

Relevant articles and documents

Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring

Migrastatin and isomigrastatin analogues have been synthesised in order to contribute to structure-activity studies on tumour cell migration inhibitors. These include macrocycles varying in ring size, functionality and alkene stereochemistry, as well as glucuronides. The synthesis work included application of the Saegusa-Ito reaction for regio- and stereoselective unsaturated macroketone formation, diastereoselective Brown allylation to generate 9-methylmigrastatin analogues and chelation-induced anomerisation to vary glucuronide configuration. Compounds were tested in vitro against both breast and pancreatic cancer cell lines and inhibition of tumour cell migration was observed in both wound-healing (scratch) and Boyden chamber assays. One unsaturated macroketone showed low affinity for a range of secondary drug targets, indicating it is at low risk of displaying adverse side effects.

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Synthesis and antiviral activities of synthetic glutarimide derivatives

A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza vi

MIGRASTATIN ANALOG COMPOSITIONS AND USES THEREOF

In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.