6258-28-2

Usage

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 11, p. 589, 1963 DOI: 10.1248/cpb.11.589

InChI:InChI=1/C7H9NO4/c9-5-1-4(3-7(11)12)2-6(10)8-5/h4H,1-3H2,(H,11,12)(H,8,9,10)

Upstream product

• 91341-04-7 diethyl 3-(cyanomethyl)glutarate 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 1378847-10-9 C₈H₈N₂O₄ 
• 856943-33-4 C₇H₉NO₄ 
• 91248-21-4 diethyl β-cyanomethylideneglutarate 
• 57056-39-0 3-carboxymethylglutaric acid 

Downstream Products

• 112521-30-9 N-β-(3,4-Dimethoxyphenethyl)-3-(6,7-dimethoxy-3,4-dihydro-1-isoquinolylmethyl)glutarimide 
• 23762-79-0 N-cyclohexyl-2-(2,6-dioxo-piperidin-4-yl)-acetamide 
• 2066-88-8 (2,6-dioxo-piperidin-4-yl)-acetaldehyde 
• 1252655-68-7 4-{2-[4-(2-tert-butylphenyl)piperazin-1-yl]-2-oxoethyl}piperidine-2,6-dione 
• 1354945-10-0 C₂₆H₃₇N₅O₄S 
• 21997-04-6 (C₆H₅)2SbO₂CCH₂C₅H₆NO₂ 
• 112521-28-5 N-β-(3,4-Dimethoxyphenethyl)-3-(3,4-dimethoxyphenethylcarbamoylmethyl)glutarimide 
• 112521-27-4 3-(3,4-Dimethoxyphenethylcarbamoylmethyl)glutarimide 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOSITIONS

The object of the present invention is to provide a pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-κB. The pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-κB contains DTCM glutarimide of the Formula (I) as an effective ingredient, thereby being able to inhibit nitric oxide (NO)production and prostaglandin production.

Synthesis and antiviral activities of synthetic glutarimide derivatives

A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza vi

Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB

Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity agai

Synthesis and Biological Activity of 3-(6,7-Dimethoxy-1,2,3,4-tetrahydro-1-isoquinolylmethyl)glutarimide

Condensation of 3-carboxymethylglutarimide (5) with 3,4-dimethoxyphenethylamine gives the required 3-(3,4-dimethoxyphenethylcarbamoylmethyl)glutarimide (6) along with N-β-(3,4-dimethoxyphenethyl)-3-(3,4-dimethoxyphenethylcarbamoylmethyl)glutarimide (7).Th