2066-89-9 Usage
Originator
Pasinazid, Yick-Vic Chemicals
Uses
Different sources of media describe the Uses of 2066-89-9 differently. You can refer to the following data:
1. antibacterial (tuberculostatic)
2. Pasiniazid is an antituberculous agents against several species of rapidly growing mycobacteria (RGM).
Manufacturing Process
10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative
Therapeutic Function
Antitubercular
Check Digit Verification of cas no
The CAS Registry Mumber 2066-89-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,6 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2066-89:
(6*2)+(5*0)+(4*6)+(3*6)+(2*8)+(1*9)=79
79 % 10 = 9
So 2066-89-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO3.C6H7N3O/c8-4-1-2-5(7(10)11)6(9)3-4;7-9-6(10)5-1-3-8-4-2-5/h1-3,9H,8H2,(H,10,11);1-4H,7H2,(H,9,10)
2066-89-9Relevant articles and documents
Conformations and interactions in pasiniazid: A spectroscopic and computational characterization
Li, Zhen,Wang, Yude,Chen, Sheng,Li, Linwei,Sun, Tiemin
, p. 179 - 186 (2017)
In this work, the conformations of isonicotinic acid hydrazide 4-aminosalicylate (pasiniazid) has been comprehensively investigated by analyzing the potential binding site on isoniazid and para-aminosalicylic acid. The powder X-ray diffraction and vibrational spectroscopy analysis with quantum chemical calculation are utilized to characterize the appropriate conformation of pasiniazid. Two hydrogen-bond systems are found in pasiniazid and the relevant vibrational modes have been assigned with the help of potential energy distribution analysis. Natural bond orbital analysis is implemented for evaluating interactions in pasiniazid. The result indicates that the intermolecular interaction is responsible for the stabilization of this complex. Furthermore, molecular electrostatic potential provides an intuitive vision for intermolecular interaction between isoniazid and para-aminosalicylic acid. The chemical stability is estimated by the frontier molecular orbitals analysis.
