206647-29-2Relevant academic research and scientific papers
Self-assembly of enantiopure and racemic 2,2′,6,6′-tetrasubstituted biaryl tectons into hydrogen bonded chiral squares and infinite chiral square layers
Holy, Petr,Zavada, Jiri,Cisarova, Ivana,Podlaha, Jaroslav
, p. 3035 - 3045 (2007/10/03)
Both chiral and achiral hydrogen bonding o-,o-,o′-,o′-tetrasubstituted biaryls often exhibit unique self-assembling properties giving rise to chiral square cyclotetramers. The individual chiral squares self-assemble further with the formation of infinite layers which are either achiral or are chiral (homochiral). A priori analysis reveals various hydrogen bonding modes which may take part in the self-assembly, differing each from the other by structure and symmetry of the resulting squares and layers. Results of the theoretical analysis are compared with the experimental findings obtained from X-ray crystallographic analysis of three novel and two already known isosteric biaryl tectons, (S)-2a, (RS)-2a, 3a, (S)-5 and (RS)-5, respectively.
The activated core approach to combinatorial chemistry: A selection of new core molecules
Pryor, Kent E.,Shipps Jr., Gerald W.,Skyler, David A.,Rebek Jr., Julius
, p. 4107 - 4124 (2007/10/03)
Four new activated core molecules suitable for use in solution-phase combinatorial organic chemistry have been prepared. These molecules represent an attempt to further explore shape-space and increase the structural diversity of prepared libraries, as well as to incorporate recognition elements in the cores to increase the chances for interaction with biological targets. Demonstrations of deconvolution strategies used to simplify complex libraries and build individual molecular species based on the cores are also provided.
