206655-89-2

Upstream product

• 111651-40-2 1,6-diazido-1,6-dideoxy-3,4-O-methylethylidene-L-iditol 
• 63699-97-8 1,2:5,6-dianhydro-3,4-O-methylethylidene-L-iditol 
• 100-39-0 benzyl bromide 
• 206655-88-1 1,6-diazido-2,5-di-O-benzyl-1,6-dideoxy-3,4-O-methylethylidene-L-iditol 

Downstream Products

• 206655-91-6 (5S,6R,7R,8S)-5,8-dibenzyloxy-6,7-dihydroxy-6,7-O-methylethylidene-2-(N-benzyl)-imino-1,3-diazonane 
• 206655-90-5 (4S,5R,6R,7S)-5,8-dibenzyloxymethyl-6,7-dihydroxy-6,7-O-methylethylidene-1,3-diazepan-2-thione 

Relevant academic research and scientific papers

Synthesis of C2-symmetric guanidino-sugars as potent inhibitors of glycosidases

A series of enantiomerically pure C2-Symmetric guanidino-sugars was synthesized from D-mannitol. The first method described involves direct opening of a bis-epoxide by guanidine, whereas the second one deals with a mercury-catalyzed transformation of a cyclic thiourea into a N,N',N'- trisubstituted guanidine as a key step. The biological activity of these compounds towards several glycosidases has been evaluated. One of them (5) was found to selectively inhibit α-L-fucosidase of bovin kidney (2.8 μM). (C) 2000 Elsevier Science Ltd.

Synthesis of C2-symmetrical cyclic guanidino-sugars from D-mannitol

An efficient method for the synthesis of C2-symmetrical cyclic guanidino-sugars has been developed from 1,2:5,6-dianhydro-3,4-O-methylethylidene-D-mannitol or L-iditol.