206755-15-9

Upstream product

• 206760-76-1 methyl (1RS)-2,2-((R,R)-cycloheptane-1,2-dioxy)cyclopentanecarboxylate 
• 10472-24-9 methyl 2-oxocyclopentane-1-carboxylate 
• 10310-21-1 2-Amino-6-chloropurin 
• 249536-90-1 (1S,5S)-5-benzyl-5-hydroxymethyl-2-cyclopentenol 
• 206755-11-5 methyl (1S,4S)-1-benzyl-4-hydroxy-2-cyclopentenecarboxylate 
• 249536-99-0 methyl (1S,4S)-4-acetoxy-1-benzyl-2-cyclopentenecarboxylate 
• 206755-05-7 methyl (1R)-1-benzyl-2-[(1'R,2'R)-2'-hydroxycycloheptan-1'-yl]oxy-2-cyclopenten-1-carboxylate 
• 249536-87-6 (1S,4S)-4-benzyl-4-(tert-butyldiphenylsilyloxymethyl)-2-cyclopentenol 
• 206760-83-0 methyl (1R)-1-benzyl-2,2-[(1'R,2'R)-cycloheptane-1',2'-dioxy]-3-cyclopentenecarboxylate 
• 206760-81-8 methyl (1R,3S)-1-benzyl-2,2-[(1'R,2'R)-cycloheptane-1',2'-dioxy]-3-iodo-1-cyclopentane-carboxylate 

Relevant academic research and scientific papers

Enantio- and diastereoselective synthesis of 4'-α-substituted carbocyclic nucleosides

Enantio- and diastereoselective synthesis of 4-α-alkylcarbovir derivatives 5 were achieved based on Sakai's asymmetric alkylation of β- keto esters. The key carbocyclic intermediate 14 was synthesized from 8 via an eleven-step sequence. Coupling of 14 with 2-amino-6-chloropurine followed by desilylation and subsequent hydrolysis gave the target compounds 5 in moderate yields.