206760-27-2Relevant academic research and scientific papers
Preparation of cycloalkane-fused dihydropyrimidin-4(3H)-one enantiomers
Szakonyi, Zsolt,Fueloep, Ferenc,Bernath, Gabor,Toeroek, Gabriella,Peter, Antal
, p. 993 - 999 (2007/10/03)
Racemic cis-2-amino-1-cyclopentane- or -cyclohexane-1-carboxylic acid was reacted with (R)-α-methylbenzylamine to form homochiral amides 3, 4 and 8, 9. The ring closures of 3, 4 and 8, 9 with aryl imidates resulted in cyclopentane cis-fused and cyclohexane cis- and trans-fused dihydropyrimidin- 4-one enantiomers with loss of the N-substituent. The absolute configurations were determined by hydrolysis of 5, 6 and 10-13 to the corresponding amino acids.
