54867-08-2Relevant academic research and scientific papers
A novel, microwave-assisted method for the synthesis of alicyclic-condensed 5H-1,4,6,7-tetrahydro-1,4-diazepin-5-ones
Balázs, árpád,der Eycken, Erik Van,Fül?p, Ferenc
, p. 4333 - 4335 (2008/12/21)
An efficient, high-yielding method has been developed for the synthesis of cycloalkane-fused and phenyl-substituted 1,4-diazepin-5-ones from β-amino acids. The process involves the oxidative cleavage of a terminal olefin bond and an acid-catalyzed, microw
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids
Wang, Yan,Jia, Shaojuan,Tseng, Ben,Drewe, John,Cai, Sui Xiong
, p. 6178 - 6182 (2008/04/02)
As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 amino acid by a 2-aminoaryl acid or other non-natural amino acids. Several of these compounds, such as 6l and 6p, were
An Efficient Synthesis of cis- and trans-2-Aminocyclohexanecarboxamides and Their N-Substituted Derivatives
Goendoes, Gyoergy,Szecsenyi, Istvan,Dombi, Gyoergy
, p. 591 - 593 (2007/10/02)
In this paper we describe a new approach to cis- and trans-2-aminocyclohexanecarboxamides and their N-substituted derivatives, which proceeds much faster and in higher yields than the methods described in the literature and usually employed in peptide che
