206761-84-4

Usage

Uses

Used in Agricultural and Horticultural Industries:
3-Phenoxybenzhydrazide is used as a herbicide for controlling broadleaf weeds and grasses in various crops. It is applied to selectively target and eliminate unwanted plants without causing harm to the desired crops, thus maintaining the productivity and quality of agricultural and horticultural produce.
Used in Weed Management:
3-Phenoxybenzhydrazide is used as a plant growth regulator to manage weed populations in farming and landscaping. By disrupting the growth cycle of weeds, PBH helps in reducing their numbers and preventing their spread, thereby protecting the cultivated plants and enhancing the overall aesthetic of landscapes.

InChI:InChI=1/C13H12N2O2/c14-15-13(16)10-5-4-8-12(9-10)17-11-6-2-1-3-7-11/h1-9H,14H2,(H,15,16)

Upstream product

• 535-80-8 3-chlorobenzoate 
• 108-95-2 phenol 
• 100-67-4 potassium phenolate 
• 618-89-3 methyl 3-bromobenzoate 
• 3739-38-6 3-phenoxybenzoic acid 
• 50789-43-0 methyl 3-phenoxybenzoate 

Downstream Products

• 1296210-43-9 N'-(3-phenoxybenzoyl)-2-(5-nitrofuran-2-yl)-1H-benzo[d]imidazole-5-carbohydrazide 
• 1296210-52-0 N'-(3-phenoxybenzoyl)-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazole-5-carbohydrazide 
• 1145661-19-3 5-(3-phenoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione 
• 223477-43-8 3-Phenoxy-benzoic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 

Relevant academic research and scientific papers

Synthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives

The re-emergence of tuberculosis (TB) as a global health problem over the past few decades, accompanied by the rise of drug-resistant strains of Mycobacterium tuberculosis, emphasizes the need for discovery of new therapeutic drugs against this disease. The emerging serious problem both in terms of TB control and clinical management prompted us to synthesize a novel series of heterocyclic o/m/p substituted diphenyl ether derivatives and determine their activity against H37Rv strain of Mycobacterium. All 10 compounds inhibited the growth of the H37Rv strain of mycobacterium at concentrations as low as 1 μg/mL. This level of activity was found comparable to the reference drugs rifampicin and isoniazid at the same concentration. Molecular modeling of the binding of the diphenyl ether derivatives on enoyl-ACP reductase, the molecular target site of triclosan, indicated that these compounds fit within the binding domain occupied by triclosan. Hence the diphenyl ether derivatives tested in this study were docked to ENR and the binding of the diphenyl ether derivatives was also estimated using a variety of scoring functions that have been compiled into the single consensus score. As the scores ranged from 47.27% to 65.81%, these bioactive compounds appear to have a novel mechanism of action against M. tuberculosis, and their structural features should be studied further for their potential use as new antitubercular drugs.

Synthesis of some novel 1-aminomethyl-3-benzoylhydrazono-2-indolinones as potential antiinflammatory agents

Acid-catalysed condensation of hydrazides 3, obtained from substituted phenoxybenzoic acids 1 with indolin-2,3-dione 4, results into hydrazono-2-indolinones 5. Compounds 5 when subjected to Mannich reaction with different cyclic secondary amines yield 1-aminomethyl-3-benzoylhydrazono-2-indolinones 6 (Mannich bases). All these compounds (6a-i) exhibit significant antiinflammatory activity.