206767-50-2Relevant academic research and scientific papers
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors
Maryanoff, Bruce E.,McComsey, David F.,Martin, Gregory E.,Shank, Richard P.
, p. 983 - 988 (2007/10/03)
We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and α-1 receptors, as well as antipsychotic activity in vivo.
