206767-65-9Relevant academic research and scientific papers
5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF
-
Page/Page column 35, (2009/12/23)
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of maki
Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors
Maryanoff, Bruce E.,McComsey, David F.,Martin, Gregory E.,Shank, Richard P.
, p. 983 - 988 (2007/10/03)
We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and α-1 receptors, as well as antipsychotic activity in vivo.
