20680-01-7

Usage

Functional groups

Thiourea derivative, hydroxyphenyl group, prop-2-en-1-yl group

Chemical structure

Contains a nitrogen atom with two substituents (hydroxyphenyl and prop-2-en-1-yl groups)

Potential pharmaceutical applications

Antioxidant, anti-inflammatory, and anticancer properties

Interaction with biological systems

Ability to interact with biological systems due to its functional groups

Drug discovery and development

Subject of interest in drug discovery and development

Chemical modifications and derivatization

Suitable for further chemical modifications and derivatization to enhance activity and selectivity for specific therapeutic applications

Upstream product

• 123-30-8 4-amino-phenol 
• 57-06-7 N-allyl isothiocyanate 

Downstream Products

• 1330061-48-7 4-(3-allylthioureido)phenyl sulfamate 
• 328106-79-2 3-allyl-2-(p-hydroxyphenylimino)-4-phenyl-3H-thiazole 

Relevant academic research and scientific papers

Synthesis of new thioureas derivatives and evaluation of their efficacy as proliferation inhibitors in mcf-7 breast cancer cells by using99m tc-mibi radiotracer

Background & Objective: Anti-tumor activity of some thioureas derivatives is well documented in literature and received considerable attention. The present study aims to synthesize and characterize some novel thioureas and carbonylthioureas as anti-tumor

CARBONIC ANHYDRASE INHIBITORS

A carbonic anhydrase IX (CA IX) inhibitor which comprises a compound of general formula: R—NH—CX—NH—(CH2)n—Ar-Q-SO2—NH2 or a pharmaceutically-acceptable salt, derivative or prodrug thereof; wherein n=0, 1 or 2; Q is O or NH; X is O or S; and R comprises an organic substituent group.

Regioselective synthesis of novel 3-allyl-2-(substituted imino)-4-phenyl-3H-thiazole and 2,2′-(1,3-phenylene)bis(3-substituted-2- imino-4-phenyl-3H-thiazole) derivatives as antibacterial agents

Several novel 3-allyl-2-(substituted imino)-4-phenyl-3H-thiazole derivatives were synthesized by the reaction of allyl-thioureas and 2-bromoacetophenone. We also report the synthesis of bis-allyl-3H thiazoles using the reaction of various isothiocyanates

CARBONIC ANHYDRASE INHIBITORS

A carbonic anhydrase IX (CA IX) inhibitor which comprises a compound of general formula: R-NH-CX-NH-(CH2)n-Ar-Q-SO2-NH2 or a pharmaceutically-acceptable salt, derivative or prodrug thereof; wherein n = 0, 1 or 2; Q is O or NH; X is O or S; and R comprises an organic substituent group.