2068119-11-7

Basic information

• Product Name: N-(2,4-difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide
• CAS NO: 2068119-11-7
• Molecular Weight: 518.557
• Mol File: 2068119-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,4-difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide(2068119-11-7)
• EPA Substance Registry System: N-(2,4-difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide(2068119-11-7)

Safety Data

• Hazardous Substances Data: 2068119-11-7(Hazardous Substances Data)

Upstream product

• 383135-47-5 2-[4-(ethanesulfonyl)phenyl]acetic acid 
• 141-78-6 ethyl acetate 

Relevant articles and documents

Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003

The retinoic acid receptor-related orphan receptor-gamma-t (RORγt) is the master transcription factor responsible for regulating the development and function of T-helper 17 (Th17) cells, which are related to the pathology of several autoimmune disorders. Therefore, RORγt is an attractive drug target for such Th17-mediated autoimmune diseases. A structure-activity relationship (SAR) study of lead compound 1 yielded a novel series of RORγt inhibitors, represented by compound 6. Detailed SAR optimization, informed by X-ray cocrystal structure analysis, led to the discovery of a potent orally bioavailable RORγt inhibitor 25, which inhibited IL-17 production in the skin of IL-23-treated mice by oral administration.