206861-68-9

Upstream product

• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 42506-03-6 pixyl chloride 

Downstream Products

• 206861-69-0 {[2-(9-Phenyl-9H-xanthen-9-yloxy)-ethylamino]-methyl}-phosphonic acid dimethyl ester 
• 206861-70-3 ({[2-(6-Benzoylamino-purin-9-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester 
• 206861-71-4 ({[2-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester 
• 206861-73-6 ({[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-[2-(9-phenyl-9H-xanthen-9-yloxy)-ethyl]-amino}-methyl)-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Synthesis and hybridization properties of an acyclic achiral phosphonate DNA analogue

Protected N-(2-hydroxyethyl)-N-(nucleobase- acetyl)aminomethanephosphonic acids (6a-d) of all four DNA nucleobases have been prepared and oligomerized by solid-phase synthesis. Four DNA decamers containing 1-10 of these 'PPNA' monomers were prepared and evaluated by T(m) measurements (medium salt) for binding to their DNA and RNA complements. One central modification reduced the binding strongly (?T(m) =-10 °C), but contiguous PPNA monomers gave smaller effects, and the all-PPNA decamer bound to RNA with a ?T(m) of -1.2°C per modification. Thus PPNA oligomers are inferior DNA and RNA binders compared to the closely related and strongly binding PNA oligomers.