206872-94-8Relevant academic research and scientific papers
Studies on Quinazolinones as Dual Inhibitors of Pgp and MRP1 in Multidrug Resistance
Wang, Shouming,Ryder, Hamish,Pretswell, Ian,Depledge, Paul,Milton, John,Hancox, Timothy C.,Dale, Ian,Dangerfield, Wendy,Charlton, Peter,Faint, Richard,Dodd, Rory,Hassan, Stephanie
, p. 571 - 574 (2007/10/03)
The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.
Anthranilic acid derivatives as multi drug resistance modulators
-
, (2008/06/13)
Anthranilic acids of formula (I): wherein each of R to R9is an organic substituent, n is 0 or 1, m is 0 or an integer of 1 to 6, q is 0 or 1, X is a direct bond, O, S, —S—(CH2)por —O—(CHO2)p— wherein p is from 1 to 6 and Ar is an unsaturated carbocyclic or heterocyclic group, and the pharmaceutically acceptable salts thereof, have activity as inhibitors of P-glycoprotein and may thus be used, inter alia, as modulators of multidrug resistance in the treatment of multidrug resistant cancers, for example to potentiate the cytotoxicity of a cancer drug.
