206882-39-5Relevant academic research and scientific papers
Discovery of a novel benzyloxyisoquinoline derivative with potent anti- Helicobacter pylori activity
Yoshida, Yoshiki,Barrett, David,Azami, Hidenori,Morinaga, Chizu,Matsumoto, Yoshimi,Takasugi, Hisashi
, p. 1897 - 1902 (1998)
The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3- acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram- positive and Gram-negative bacteria.
