Discovery of a novel benzyloxyisoquinoline derivative with potent anti- Helicobacter pylori activity

Article abstract of DOI:10.1016/S0960-894X(98)00335-7

The synthesis and in vitro optimization of the anti-Helicobacter pylori activity of a novel series of benzyloxyisoquinoline derivatives discovered by a random screening process, are described. FR180102 (7f), having a 3- acetamido-2,6-dichlorobenzyl moiety, was found to have extremely potent activity against H. pylori and no effect against a series of common Gram- positive and Gram-negative bacteria.