2069-36-5

Usage

Uses

Used in Organic Synthesis:
2,3,4,5,6-PENTAFLUOROPHENYL 4-METHYLBENZENESULFONATE is used as a reagent in organic synthesis for its ability to facilitate the formation of carbon-carbon and carbon-heteroatom bonds. Its unique structure and reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3,4,5,6-PENTAFLUOROPHENYL 4-METHYLBENZENESULFONATE is used as a building block for the preparation of various pharmaceuticals. Its properties allow for the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
2,3,4,5,6-PENTAFLUOROPHENYL 4-METHYLBENZENESULFONATE is also utilized in the agrochemical industry, where it serves as a key component in the synthesis of various agrochemicals. Its role in the development of new agrochemicals contributes to advancements in agriculture and pest control.
Used in Specialty Chemicals Manufacturing:
In the manufacturing of dyes, pigments, and other specialty chemicals, 2,3,4,5,6-PENTAFLUOROPHENYL 4-METHYLBENZENESULFONATE is used as a cross-coupling reagent. Its ability to form stable bonds with other molecules makes it an essential component in the production of high-quality specialty chemicals.
Overall, 2,3,4,5,6-PENTAFLUOROPHENYL 4-METHYLBENZENESULFONATE is a versatile chemical compound with a wide range of applications across various industries, making it an important asset in the development of new products and technologies.

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 98-59-9 p-toluenesulfonyl chloride 
• 5720-05-8 4-methylphenylboronic acid 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 

Downstream Products

• 1143-01-7 N-hexyl p-toluenesulfonamide 
• 1536-23-8 2,3,4,5,6-pentafluorobenzophenone 

Relevant academic research and scientific papers

One-Pot Synthesis of Pentafluorophenyl Sulfonic Esters via Copper-Catalyzed Reaction of Aryl Diazonium Salts, DABSO, and Pentafluorophenol

Pentafluorophenyl (PFP) sulfonic esters were synthesized via a copper-catalyzed one-pot multicomponent reaction of aryl diazonium tetrafluoroborate, DABSO (DABCO·(SO2)2), and pentafluorophenol. The reaction system provided the desired pentafluorophenyl sulfonic esters in good yields and exhibited excellent functional group tolerance. In addition, the generated PFP sulfonic esters were successfully applied in Sonogashira, Suzuki, Chan-Evans-Lam, and decarboxylative coupling reactions.

Copper-Catalyzed Synthesis of Activated Sulfonate Esters from Boronic Acids, DABSO, and Pentafluorophenol

The synthesis of pentafluorophenyl (PFP) sulfonate esters based on the Pd-catalyzed sulfination of aryl and heteroaryl boronic acids is reported. The sulfinate intermediates are converted in situ to the corresponding sulfonate esters using a copper-catalyzed oxidative process, providing a broad range of PFP esters in good yields.

Multicomponent Coupling Reaction of Perfluoroarenes with 1,3-Butadiene and Aryl Grignard Reagents Promoted by an Anionic Ni(II) Complex

An anionic Ni complex was isolated and its structure determined by X-ray crystallography. With such an anionic complex as a key intermediate, a regio- and stereoselective multicomponent coupling reaction of perfluoroarenes, aryl Grignard reagents, and 1,3-butadiene in a 1:1:2 ratio was achieved, resulting in the formation of 1,6-octadiene derivatives containing two aryl groups, one from the perfluoroarene and the other from the aryl Grignard reagent, at the 3- and 8-positions, respectively.