207119-82-2

Basic information

• Product Name: Benzonitrile, 4-(3-furanyl)-
• CAS NO: 207119-82-2
• Molecular Formula: C11H7NO
• Molecular Weight: 169.183
• Mol File: 207119-82-2.mol

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(3-furanyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(3-furanyl)-(207119-82-2)
• EPA Substance Registry System: Benzonitrile, 4-(3-furanyl)-(207119-82-2)

Safety Data

• Hazardous Substances Data: 207119-82-2(Hazardous Substances Data)

Upstream product

• 55552-70-0 furan-3-boronic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 201230-82-2 carbon monoxide 
• 80151-16-2 3-(4-cyanophenyl)-2-propyne-1-ol 

Relevant articles and documents

Palladium/tetraphosphine catalyzed suzuki cross-coupling of heteroarylboronic acids with aryl halides

(Chemical Equation Presented) cis,cis,cis-1,2,3,4- Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H 5)]2 efficiently catalyses the Suzuki reaction of heteroarylboronic acids with aryl bromides and also the coupling of arylboronic acids with heteroaryl bromides. The coupling of thiophene- or benzothiopheneboronic acids, furan- or benzofuranboronic acids and 3-pyridineboronic acid with a variety of aryl bromides gave the corresponding coupling products in good yields. However, in most cases, better results in terms of ratio substrate/catalyst were obtained for the reverse reaction using heteroaryl bromides with arylboronic acids.

Synthesis of 3-substituted furans by hydroformylation

A simple and novel method for the synthesis of 3-substituted furans by the hydroformylation of substituted propargylic alcohols is described using rhodium acetate and triphenylphosphine in dichloromethane. The hydroformylation reaction proceeds in a regio

Suzuki coupling reactions of heteroarylboronic acids with aryl halides and arylboronic acids with heteroaryl bromides using a tetraphosphine/palladium catalyst

cix,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/ [PdCl(C3H5)]2 efficiently catalyses the Suzuki reaction of heteroarylboronic acids with aryl bromides and also the coupling of arylboronic acids with heteroaryl bromides. The coupling of thiopheneboronic acids, 3-furanboronic acid and 3-pyridineboronic acid with a variety of aryl bromides gave the corresponding adducts in good yields. However, in most cases, better results in terms of substrate/catalyst ratio were obtained for the reaction of heteroaryl bromides with arylboronic acids. Georg Thieme Verlag Stuttgart.

Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use

The present invention is directed to compound of the formula I: STR1 wherein R1, R2, R3, R4, R5, X, Y, and STR2 are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.