207120-52-3Relevant academic research and scientific papers
Amine-promoted asymmetric (4+2) annulations for the enantioselective synthesis of tetrahydropyridines: A traceless and recoverable auxiliary strategy
Hu, Pengfei,Hu, Jian,Jiao, Jiajun,Tong, Xiaofeng
, p. 5319 - 5322 (2013)
Gone, without a trace: The in situ reaction of 2-(acetoxymethyl)buta-2,3- dienoate and a secondary amine produces a 2-methylene-3-oxobutanoate equivalent that can be used in asymmetric [4+2] annulations with N-tosylimines to provide tetrahydropyridines in
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
-
, (2008/06/13)
The present invention is directed to compound of the formula I: STR1 wherein R1, R2, R3, R4, R5, X, Y, and STR2 are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds.
Design and synthesis of novel conformationally restricted HIV protease inhibitors
Salituro, Francesco G.,Baker, Christopher T.,Court, John J.,Deininger, David D.,Kim, Eunice E.,Li, Biquin,Novak, Perry M.,Rao, Bhisetti G.,Pazhanisamy,Porter, Margaret D.,Schairer, Wayne C.,Tung, Roger D.
, p. 3637 - 3642 (2007/10/03)
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.
