221045-94-9

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 111060-52-7 (S)-2-(dibenzylamino)-3-phenylpropan-1-ol 
• 857489-55-5 (S)-(-)-2-(dibenzylamino)-3-phenyl-1-(tert-butyldimethylsilyloxy)propane 

Downstream Products

• 314050-81-2 N-[(S)-1-benzyl-2-(tert-butyldimethylsilyloxy)ethyl]-N'-[(S)-1-phenylethyl]thiourea 
• 1186504-55-1 C₂₃H₃₅NOSi 
• 194599-67-2 N-[(S)-3-((S)-3-Benzyl-5-oxo-morpholin-4-yl)-2-hydroxy-propyl]-N-cyclopentylmethyl-4-methoxy-benzenesulfonamide 
• 207120-52-3 (S)-2-chloro-N-(1-hydroxy-3-phenylpropan-2-yl)acetamide 
• 101250-48-0 (S)-5-benzylmorpholin-3-one 
• 281206-87-9 (3S,7S,8S)-3-benzyl-7,8-diphenyl-6-ethoxycarbonyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene 

Relevant academic research and scientific papers

Simple amino silyl ether organocatalyst for asymmetric hetero Diels–Alder reaction of isatins with enones

New two catalysts component system comprising of a primary β-amino silyl ethers as an organocatalyst and N-protected amino acids as a co-catalyst put together worked as an efficient organocatalyst system in the hetero Diels–Alder reaction of isatins with enones affording the chiral spirooxindole-tetrahydropyranones in good chemical yields and stereoselectivities (up to 94%, up to dr 78:22., up to 85% ee).

Synthesis of novel NHC–Rh complexes with anti-tumor activity against MCF-7 human breast cancer cells

A series of novel N-heterocyclic carbene rhodium complexes (NHC–Rh), containing benzimidazole framework, were prepared smoothly by a five-step route. Their structures were elucidated based on spectral techniques, including NMR and MS spectrometry. Along with several NHC–Rh complexes we prepared before, the compounds prepared herein were evaluated for their cytotoxicities against MCF human breast cancer cells and several of them showed strong activities with IC50 values ranging from 0.38 to 1.18μM, which were better than the positive control paclitaxel.

Chirality n-heterocyclic carbine precursor compound with benzoglioxaline frameworks and preparation method and application thereof

The invention discloses chirality n-heterocyclic carbine precursor compound with benzoglioxaline frameworks and a preparation method and application thereof. Five steps of reaction can simply and effectively compound a series of chirality benzoglioxaline

Addition of allylzinc to a-amino acid-derived imines: Synthesis of diamino alcohols by Hydroboration

Imines obtained by condensation of Z-pro- tected or Boc-protected α-amino aldehydes with α-amino tert-butyl esters or with O-silyl-protected amino alcohols were reacted with preformed allyl zinc yielding homoal- lylamines with yields around 50% and selectivities ranging from 50:50 to 90:10. Hydroboration of the terminal double bond furnished diamino alcohols with yields up to 97%. The configuration of the substrates was determined by X-ray-crystallographic analysis of a hydroboration product and comparison of physical data. Springer-Verlag 2010.

Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis

The comparative characterization of a series of 4-acyl-1,6-dialkylpiperazin-2-ones as potent cell entry inhibitors of the hemorrhagic fever arenavirus Lassa (LASV) is disclosed. The resolution and examination of the individual enantiomers of the prototypi

Synthesis of sultam scaffolds via intramolecular oxa-michael and diastereoselective baylis-hillman reactions

(Chemical Equation Presented) A divergent synthetic approach to new sultams utilizing intramolecular oxa-Michael and Baylis-Hillman reactions of readily prepared vinyl sulfonamides and suitably protected amino alcohols, is reported. A variety of seven- an

A tuneable method for N-debenzylation of benzylamino alcohols

(Chemical Equation Presented) N-lodosuccinmide provides a mild, convenient, and tuneable reagent for the selective mono- or didebenzylation in representative, multifunctionalized carbohydrate and amino acid derived N-dibenzylamines with neighboring O-func

Asymmetric induction during Yang cyclization of α-oxoamides: The power of a covalently linked chiral auxiliary is enhanced in the crystalline state

γ-Hydrogen abstraction has been revealed to be the primary photoprocess in the crystalline state of α-oxoamides through photochemical and X-ray structural studies. The outstanding ability of a covalent chiral auxiliary in generating asymmetric induction i

Modified guanidines as potential chiral superbases. 3. Preparation of 1,4,6-triazabicyclooctene systems and 1,4-disubstituted 2-iminoimidazolidines by the 2-chloro-1,3-dimethylimidazolinium chloride-induced cyclization of guanidines with a hydroxyethyl substituent

Simple preparation methods of modified guanidines have been explored as potential chiral superbases. Thus, 3,7,8-trisubstituted and 3,6,7,8-tetrasubstituted 1,4,6-triazabicyclooctene systems were prepared from (1S,2S)-1,2-diphenylethylenediamine through stepwise 2-chloro-1,3-dimethylimidazolinium chloride (DMC)-induced cyclizations of protected thioureas to the corresponding 2-iminoimidazolidines and then of 2-(2-hydroxyethylimino)imidazolidines to the bicyclic systems. Linear guanidines with a 2-hydroxyethyl functional group were prepared by the reaction of carbodiimides with 2-amino alcohols. Reaction of linear-type guanidines with DMC followed by base treatment afforded 1,4-disubstitued 2-iminoimidazolidines. Furthermore, another type of 1,4,6-triazabicyclooctene was also prepared through double DMC-induced cyclization of guanidines with two 2-hydroxyethyl substituents.