207124-14-9Relevant academic research and scientific papers
Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy
Hirata, Yuuki,Nakamura, Seiichi,Watanabe, Nobuhide,Kataoka, Osamu,Kurosaki, Takahiro,Anada, Masahiro,Kitagaki, Shinji,Shiro, Motoo,Hashimoto, Shunichi
, p. 8898 - 8925 (2007/10/03)
A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor 8 was synthesized starting from di-tert-butyl D-tartrate (47) via an eleven-step sequence involving the regiosel
Toward the second-generation synthesis of zaragozic acids: Construction of the 2,8-dioxabicyclo[3.2.1]octane core system via tandem carbonyl ylide formation and 1,3-dipolar cycloaddition sequence
Kataoka, Osamu,Kitagaki, Shinji,Watanabe, Nobuhide,Kobayashi, Jun-ichi,Nakamura, Sei-ichi,Shiro, Motoo,Hashimoto, Shun-ichi
, p. 2371 - 2374 (2007/10/03)
A highly efficient construction of the 2,8-dioxabicyclo[3.2.1]octane core structure of zaragozic acids, inhibitors of the enzyme squalene synthase, has been achieved by exploiting the sequence of rhodium(II)- mediated intramolecular carbonyl ylide formati
