207224-81-5

Basic information

• Product Name: (2R,3R)-2-(2,4-Difluoro-phenyl)-3-{4-[4-(2H-tetrazol-5-yl)-phenyl]-thiazol-2-yl}-1-[1,2,4]triazol-1-yl-butan-2-ol
• CAS NO: 207224-81-5
• Molecular Weight: 480.501
• Mol File: 207224-81-5.mol

Chemical Properties

• CAS DataBase Reference: (2R,3R)-2-(2,4-Difluoro-phenyl)-3-{4-[4-(2H-tetrazol-5-yl)-phenyl]-thiazol-2-yl}-1-[1,2,4]triazol-1-yl-butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-2-(2,4-Difluoro-phenyl)-3-{4-[4-(2H-tetrazol-5-yl)-phenyl]-thiazol-2-yl}-1-[1,2,4]triazol-1-yl-butan-2-ol(207224-81-5)
• EPA Substance Registry System: (2R,3R)-2-(2,4-Difluoro-phenyl)-3-{4-[4-(2H-tetrazol-5-yl)-phenyl]-thiazol-2-yl}-1-[1,2,4]triazol-1-yl-butan-2-ol(207224-81-5)

Safety Data

• Hazardous Substances Data: 207224-81-5(Hazardous Substances Data)

Upstream product

• 170863-34-0 (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide 
• 170862-36-9 (2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile 
• 20099-89-2 4-Cyanophenacyl bromide 
• 1443-80-7 4-cyanophenyl methyl ketone 

Relevant articles and documents

Synthesis and antifungal activity of novel thiazole-containing triazole antifungals. II. Optically active ER-30346 and its derivatives

A series of novel thiazole-containing triazole antifungals was synthesized and evaluated for antifungal activity against a variety of clinically isolated pathogenic fungi in vitro and against systemic candidosis in vivo. These compounds showed potent antifungal activities in vitro and in vivo. In particular, (2R,3R)-3-[4-(4-cyanophenyl)thiazol-2-yl]-2-(2,4- difluorophenyl)-1-(1H-1,2,4-triazol-l-yl)-2-butanol (12g; ER-30346) showed potent and well-balanced in vitro activities and potent in vivo efficacy, and had a good safety profile.