207276-89-9

Upstream product

• 158646-89-0 6-hydroxy-2-propyl-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one 
• 207276-96-8 4-methyl-benzenesulfinic acid (1-furan-2-ylbut-3-enyl)amide 
• 188447-80-5 (S,E)-4-methyl-N-(2-furylmethylidene)benzenesulfinamide 
• 148409-93-2 (S)-N-(1-(furan-2-yl)but-3-en-1-yl)-4-methylbenzenesulfonamide 
• 134452-29-2 (S)-N-tosyl-α'-propyl-α-furfuryl amine 
• 207276-88-8 6-ethoxy-2-propyl-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one 

Downstream Products

• 207276-90-2 dithiocarbonic acid O-[6-ethoxy-2-propyl-1-(toluene-4-sulfonyl)piperidin-3-yl]ester S-methyl ester 

Relevant academic research and scientific papers

Reversal of diastereofacial selectivity in the nucleophilic addition reaction to chiral N-sulfinimine and application to the synthesis of indrizidine 223AB

Diastereoselective addition reaction of ester enolates and Grignard reagents to optically active N-sulfinimines was examined. Reversal of the diastereofacial selectivity was realized by using appropriate metal species, solvents and additives, and the β-amino esters (up to >98% de) and the homoallylic amines (up to >98% de) were obtained in good yields. β-Amino esters thus obtained were converted to the useful β-amino acids involving (R)-homoserine. Application to the synthesis of indrizidine alkaloids was also described.