134452-29-2Relevant academic research and scientific papers
Reversal of diastereofacial selectivity in the nucleophilic addition reaction to chiral N-sulfinimine and application to the synthesis of indrizidine 223AB
Koriyama, Yuji,Nozawa, Akihiro,Hayakawa, Ryuuichirou,Shimizu, Makoto
, p. 9621 - 9628 (2007/10/03)
Diastereoselective addition reaction of ester enolates and Grignard reagents to optically active N-sulfinimines was examined. Reversal of the diastereofacial selectivity was realized by using appropriate metal species, solvents and additives, and the β-amino esters (up to >98% de) and the homoallylic amines (up to >98% de) were obtained in good yields. β-Amino esters thus obtained were converted to the useful β-amino acids involving (R)-homoserine. Application to the synthesis of indrizidine alkaloids was also described.
An efficient preparation of optically active α-furfuryl amide by kinetic resolution using the modified Sharpless asymmetric epoxidation reagents
Zhou,Lu,Wang
, p. 2641 - 2654 (2007/10/02)
Kinetic resolution of α-furfuryl amide was first carried out by using the modified Sharpless asymmetric epoxidation reagent to give the slow-reacting enantiomers, (S)-1(a-h) and (R)-1(b,f) in high enantioselectivity (90-100% e.e) and high chemical yield (
An efficient preparation of optically active α-furfuryl amide by kinetic resolution using the modified sharpless asymmetric epoxidation reagent
Zhou, Wei-Shan,Lu, Zhi-Hui,Wang, Zhi-Min
, p. 1467 - 1470 (2007/10/02)
Kinetic resolution of α-furfuryl amide was first carried out by using the modified Sharpless asymmetric epoxidation reagent to give the slow-reacting enantiomers, (S)-la-f and (R)-lb,f in high enantioselectivity (90-100% e.e) and high chemical yield (45-5
