207286-80-4

Upstream product

• 4250-49-1 (4-bromophenyl)dichloroborane 
• 17435-72-2 ethyl 2-bromomethyl-2-propenoate 
• 13183-70-5 1,4-bis-(trimethylsilyl)benzene 
• 50-00-0 formaldehyd 
• 40640-98-0 3-(4-bromo-phenyl)-propionic acid ethyl ester 
• 207286-79-1 Ethyl 4-bromo-α-(diethoxyphosphinyl)benzenepropanoate 
• 55883-45-9 4-bromobenzyliodide 
• 132627-71-5 2-[(4-methylphenylsulfonyl)methyl]propenoic acid ethyl ester 
• 139139-81-4 bis(4-bromophenyl)iodonium triflate 
• 106019-40-3 α-(N-benzyloxycarbonylamino)benzyl-H-phosphonous acid 

Downstream Products

• 860256-21-9 2-(4-bromobenzyl)acrylic acid 
• 268225-39-4 (S)-2-{3-[(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-4-methyl-pentanoic acid 
• 268225-38-3 (S)-2-{3-[(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-butyric acid 
• 207286-84-8 methyl N-[3-[1,1'-biphenyl]-4-yl-2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxopropyl]-L-alaninate 
• 207286-95-1 (S)-2-{3-[(1-Benzyloxycarbonylamino-ethyl)-hydroxy-phosphinoyl]-2-biphenyl-4-ylmethyl-propionylamino}-3-phenyl-propionic acid 
• 207286-85-9 N-[3-[1,1'-biphenyl]-4-yl-2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxopropyl]-L-alanine 

Relevant academic research and scientific papers

Rhodium(iii)-catalyzed C-H allylation of electron-deficient alkenes with allyl acetates

Rhodium-catalyzed C-H allylation of acrylamides with allyl acetates is reported. The use of weakly coordinating directing group resulted in high reaction efficiency, broad functionality tolerance and excellent γ-selectivity, which opens a new synthetic pathway for the access of 1,4-diene skeletons.

Rhodium(III)-catalyzed olefinic C-H alkynylation of acrylamides using tosyl-imide as directing group

The Rh(III)-catalyzed C-H alkynylation of acrylamide derivative is realized using a hypervalent alkynyl iodine reagent. The use of a weakly coordinating directing group proved to be of critical importance. This reaction displays broad functional group tolerance and high efficiency, which opens a new synthetic pathway to access functionalized 1,3-enyne skeletons.

Aryl radical formation by copper(I) photocatalyzed reduction of diaryliodonium salts: NMR Evidence for a CuII/CuI mechanism

Photocatalyzed reduction of diaryliodonium salts was achieved by using [Cu(dpp)2][PF6] as a photoactive complex and DIPEA as a reductive quench. The application of a copper catalyst allows the generation of aryl radicals under mild conditions and maintains their reactivity for C-C bond formation processes.

(α-aminophosphino) peptide derivatives, method for making same and therapeutic applications thereof

The invention concerns compounds derived from (α-aminophosphino) peptides, of general formula (I), in which R1and R2each represents a hydrogen atom or taken together form an imine with the adjacent nitrogen atom; R3represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally, a methyl group substituted by a heterocyclic, aromatic or saturated group; R4represents a phenyl group, a benzyl group, these groups capable of being substituted or not, a hydrogen atom, an alkyl group, analkenyl group or a cycloalkyl group; R5represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl, cycloalkylmethyl group or finally a methyl group substituted by a heterocyclic, aromatic or saturated group; R6, R7and R8can in particular represent a hydrogen atom, an alkyl group, a phenyl group substituted or not . . . n is equal to 0 or 1, in the form of enantiomers, diastereoisomers or racemic mixtures, their salts, their method of preparation and their therapeutic applications.

One-pot chemoselective functionalization of arylsilanes via cascade metal-metal exchange reactions

A cascade-transmetallation sequence allows a one-pot conversion of arylsilanes into functionalized arylcoppers; they react with various types of electrophiles (allylic halides, acid chlorides, bromoalkynes); bimetallic zinc-copper-reagents can be prepared by this method either directly or in a sequential fashion.

(α-aminophosphino) peptides derivative and compositions containing same

The invention concerns (α-aminophosphino) peptide derivative compounds of general formula (I) wherein: R1and R2represent each a hydrogen atom or together form an imine with the adjacent nitrogen atom; R3represents an alkyl