20731-74-2

Basic information

• Product Name: 3-(METHYLTHIO)THIOPHENE
• Synonyms: 3-(METHYLTHIO)THIOPHENE;3-(Methylsulfanyl)thiophene;3-Thienylmethylsulfide;methyl-3-thienylsulfide;Thiophene, 3-(methylthio)-
• CAS NO: 20731-74-2
• Molecular Formula: C₅H₆S₂
• Molecular Weight: 130.23
• Product Categories: Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 20731-74-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 89-92°C 15mm
• Flash Point: 69.6 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.714mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 3-(METHYLTHIO)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(METHYLTHIO)THIOPHENE(20731-74-2)
• EPA Substance Registry System: 3-(METHYLTHIO)THIOPHENE(20731-74-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 20731-74-2(Hazardous Substances Data)

Usage

General Description

3-(Methylthio)thiophene is a chemical compound with the molecular formula C5H6S2 and a molecular weight of 126.23 g/mol. It is a member of the thiophene family and consists of a five-membered ring with four carbon atoms and one sulfur atom. The addition of a methylthio group to thiophene gives it a distinct odor and makes it an important building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It is commonly used as a flavoring agent and fragrance in the food and cosmetic industries. Additionally, 3-(methylthio)thiophene has been studied for its potential biological activities, including its anti-inflammatory and anti-fungal properties.

InChI:InChI=1/C5H6S2/c1-6-5-2-3-7-4-5/h2-4H,1H3

Upstream product

• 1192-06-9 3-thienyl lithium 
• 624-92-0 Dimethyldisulphide 
• 872-31-1 3-Bromothiophene 
• 437711-55-2 3-[(2-cyanoethyl)sulfanyl]thiophene 
• 74-88-4 methyl iodide 
• 5188-07-8 sodium thiomethoxide 
• 109-72-8 n-butyllithium 

Downstream Products

• 63359-64-8 2,5-dimethyl-3-(methylthio)thiophene 
• 1641-09-4 3-thiophenecarbonitrile 
• 1402843-21-3 2,2'-(2,5-bis(2-ethylhexyl)-1,4'-phenylene)bis(3-methylsulfinyl)thiophene 
• 34259-99-9 4-bromo-1,3-thiazole 
• 74598-24-6 3-methylthio-2-acetylthiophene 
• 60166-80-5 3-(methylthio)thiophene-2-carboxylic acid 
• 38695-58-8 3-(methylsulfonyl)thiophene 

Relevant articles and documents

Selective and efficient syntheses of phototoxic 2,2':5',2''-terthiophene derivatives bearing a functional substituent in the 3'- or the 5-position

Efficient and selective procedures have been developed to prepare on a medium scale several phototoxic 2,2':5',2''-terthiophene derivatives of general formula 2 and 3, which are characterized by a functional substituent in the 3'- or the 5-position. Most of these procedures, which are based on the construction of the 2,2':5',2''-terthiophene moiety and involve palladium-mediated carbon-carbon bond forming reactions, allow to overcome synthetic difficulties that may be found in the synthesis of compounds 2 and 3 starting from 2,2':5',2''-terthiophene (1a).

A containing oxygen race element and five fused ring conjugated molecule with the synthetic method of derivative thereof and use

The invention relates to an oxygen family element-containing penta-condensed ring conjugated molecule and its derivative synthetic method and a purpose thereof. A structure of the oxygen family element-containing penta-condensed ring conjugated molecule is shown as follows, and a structure of the derivative of the oxygen family element-containing penta-condensed ring conjugated molecule is shown as follows.

PROCESSES FOR PRODUCING 3-(METHYLTHIO) THIOPHENE

Processes are provided for producing 3-(methylthio) thiophene by (i) combining at least an alkyl lithium, one or more alkanes and an ether to form a first combination, (ii) at a temperature of about -30°C to about -25°C and over a time period of at least about 30 minutes, adding 3-bromothiophene diluted in an ether to the first combination to form a second combination, (iii) at a temperature of about -25°C to about -20°C combining at least the second combination and dimethyl disulfide, and (iv) yielding at least the 3-(methylthio) thiophene.