20731-74-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3-(METHYLTHIO)THIOPHENE is used as a key intermediate in the synthesis of various organic compounds for its ability to contribute to the development of new drugs and agrochemicals. Its structural properties make it a valuable component in creating molecules with specific therapeutic or pesticidal activities.
Used in Flavor and Fragrance Industry:
3-(METHYLTHIO)THIOPHENE is used as a flavoring agent and fragrance, capitalizing on its distinct odor to enhance the sensory experience of food and cosmetic products. Its unique scent profile allows it to contribute to the creation of complex and appealing aromas in these industries.
Used in Research and Development:
3-(METHYLTHIO)THIOPHENE is utilized in research for its potential biological activities, such as anti-inflammatory and anti-fungal properties. This application is crucial for exploring new avenues in medicine and potentially discovering novel treatments for various conditions.

InChI:InChI=1/C5H6S2/c1-6-5-2-3-7-4-5/h2-4H,1H3

Upstream product

• 872-31-1 3-Bromothiophene 
• 109-72-8 n-butyllithium 
• 624-92-0 Dimethyldisulphide 
• 5188-07-8 sodium thiomethoxide 
• 1192-06-9 3-thienyl lithium 
• 437711-55-2 3-[(2-cyanoethyl)sulfanyl]thiophene 
• 74-88-4 methyl iodide 

Downstream Products

• 38695-58-8 3-(methylsulfonyl)thiophene 
• 60166-80-5 3-(methylthio)thiophene-2-carboxylic acid 
• 74598-24-6 3-methylthio-2-acetylthiophene 
• 34259-99-9 4-bromo-1,3-thiazole 
• 63359-64-8 2,5-dimethyl-3-(methylthio)thiophene 
• 1402843-21-3 2,2'-(2,5-bis(2-ethylhexyl)-1,4'-phenylene)bis(3-methylsulfinyl)thiophene 
• 1641-09-4 3-thiophenecarbonitrile 

Relevant academic research and scientific papers

Selective and efficient syntheses of phototoxic 2,2':5',2''-terthiophene derivatives bearing a functional substituent in the 3'- or the 5-position

Efficient and selective procedures have been developed to prepare on a medium scale several phototoxic 2,2':5',2''-terthiophene derivatives of general formula 2 and 3, which are characterized by a functional substituent in the 3'- or the 5-position. Most of these procedures, which are based on the construction of the 2,2':5',2''-terthiophene moiety and involve palladium-mediated carbon-carbon bond forming reactions, allow to overcome synthetic difficulties that may be found in the synthesis of compounds 2 and 3 starting from 2,2':5',2''-terthiophene (1a).

Metal-free synthesis of biaryls from aryl sulfoxides and sulfonanilides via sigmatropic rearrangement

Treatment of aryl sulfoxides and sulfonanilides with trifluoroacetic anhydride resulted in the dehydrative metal-free construction of the corresponding unsymmetrical biaryls. The reaction would proceed via (1) the activation of aryl sulfoxide with the anhydride, (2) interrupted Pummerer reaction of the resulting arylsulfonium with sulfonanilide, (3) [3,3] sigmatropic rearrangement to cleave the transient S–N bond and to form the prospective biaryl C–C bond, and (4) global aromatization. The choice of the amino protecting group is crucial, and only N-sulfonylanilines, i.e., sulfonanilides, could participate in the formation of biaryls.

A containing oxygen race element and five fused ring conjugated molecule with the synthetic method of derivative thereof and use

The invention relates to an oxygen family element-containing penta-condensed ring conjugated molecule and its derivative synthetic method and a purpose thereof. A structure of the oxygen family element-containing penta-condensed ring conjugated molecule is shown as follows, and a structure of the derivative of the oxygen family element-containing penta-condensed ring conjugated molecule is shown as follows.

organinc semiconductor compound and organic solar cell having them

The present invention relates to a compound for an organic semiconductor material with a low band gap and an organic solar cell including the same. In the present invention, provided is a dithienobenzodithiophene derived compound which has outstanding hole mobility, a low band gap, a large light-absorbing area and a proper molecular level and accordingly is used as organic photoelectron device like an organic photo detector (OPD), an organic light emitting diode (OLED), an organic thin film transistor (OTFT) and an organic solar cell where the organic solar cell having the compound is provided, thereby leading to a power conversion efficiency (PCE).

Thiolate chemistry: A powerful and versatile synthetic tool for immobilization/functionalization of oligothiophenes on a gold surface

The synthesis and characterization of a series of quaterthiophenes (4Ts) with thiolate groups protected with 2-cyanoethyl (CNE), 2-trimethylsilylethyl (TMSE), and acetyl (Ac) groups are described. Sequential cleavage of these different protecting groups allows for the preparation of 4Ts derivatized with ferrocene and/or alkanethiol chains. The electrochemical behavior of these compounds has been analyzed in solution by cyclic voltammetry (CV). A ferrocene-derivatized dithiol 4T 14 and a dithiol 4T 15 with two TMSE-protected thiolate groups have been immobilized on a gold surface as monolayers that have been characterized by CV, ellipsometry, contact-angle measurement, and X-ray photoelectron spectroscopy (XPS). The results show that molecules 14 and 15 are doubly grafted with a horizontal orientation of the conjugated system relative to the surface. Furthermore, application of the deprotection/alkylation sequence of the remaining protected thiolate groups on a monolayer of 15 allows for efficient post-functionalization.

PROCESSES FOR PRODUCING 3-(METHYLTHIO) THIOPHENE

Processes are provided for producing 3-(methylthio) thiophene by (i) combining at least an alkyl lithium, one or more alkanes and an ether to form a first combination, (ii) at a temperature of about -30°C to about -25°C and over a time period of at least about 30 minutes, adding 3-bromothiophene diluted in an ether to the first combination to form a second combination, (iii) at a temperature of about -25°C to about -20°C combining at least the second combination and dimethyl disulfide, and (iv) yielding at least the 3-(methylthio) thiophene.

PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

3- and 3,4-bis(2-cyanoethylsulfanyl)thiophenes as building blocks for functionalized thiophene-based π-conjugated systems

The facile access to 3- and 3,4-bis(2-cyanoethylsulfanyl)thiophenes allows the straightforward synthesis of 3-alkylsulfanyl and symmetrical or unsymmetrical 3,4-dialkylsulfanylthiophenes by using a methodology based on a highly efficient sequence of deprotection/alkylation reactions of thiolate group(s).

Cyclic ketone derivatives and their medical applications

The present invention relates to cyclic ketones represented by the following formula and to drugs in which an effective component is such a cyclic ketone or a pharmacologically acceptable salt thereof.The cyclic ketones of the present invention encourage the production of blood platelets, leukocytes and erythrocytes, and can be employed in the prevention or treatment of cytopaenia brought about by cancer chemotherapy, radiotherapy or drug therapy, or by immunological abnormality, anaemia and the like.

Biotransformation of organic sulfides. Part 12. Conversion of heterocyclic sulfides to chiral sulfoxides by Helminthosporium sp. NRRL 4671 and Mortierella isabellina ATCC 42613

The enantioselective oxidation of a series of heterocyclic prochiral sulfides to chiral sulfoxides has been examined using the fungal biocatalysts Helminthosporium species NRRL 4671 and Mortierella isabellina ATCC 42613. Methylthiofuranyl and -thiophenyl