20735-46-0Relevant academic research and scientific papers
Palladium-catalyzed β-C-H arylation of aliphatic aldehydes and ketones using amino amide as a transient directing group
Dong, Cong,Wu, Liangfei,Yao, Jianwei,Wei, Kun
supporting information, p. 2085 - 2089 (2019/03/26)
This paper describes a new amino-amide-based transient directing group (TDG). The TDG can exhibit better performance in the Pd-catalyzed arylation of aliphatic aldehydes and ketones. This reaction showed good substrate compatibility and regioselectivity. The results indicated that 3-amino-N-isopropylpropionamide was more beneficial to the β-arylation of aliphatic aldehydes than other TDGs under relatively mild conditions.
