2074-67-1Relevant articles and documents
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Ivanov,B.E.,Karpova,T.I.
, (1964)
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Computer-aided optimization of phosphinic inhibitors of bacterial ureases
Vassiliou, Stamatia,Kosikowska, Paulina,Grabowiecka, Agnieszka,Yiotakis, Athanasios,Kafarski, Pawe,Berlicki, Lukasz
experimental part, p. 5597 - 5606 (2010/10/20)
Urease inhibitors can be considered as a tool to control the damaging effect of ureolytic bacteria infections in humans which occur commonly in the developed countries. Computer-aided optimization of the aminomethylphosphinate structures by modifying both their N- and P-termini led to the invention of a novel group of inhibitors of bacterial ureases. Introduction of P-hydroxymethyl group into the molecule resulted in considerable increase of the inhibitory activity against enzymes purified from Bacillus pasteurii and Proteus vulgaris as compared with their P-methyl counterparts described previously. The designed compounds represent a competitive reversible class of urease inhibitors. The most potent, N-methyl-aminomethyl-P-hydroxymethylphosphinic acid, displayed Ki = 360 nM against P. vulgaris enzyme.
Optimal conditions for preparing chloromethylphosphonic dichloride
Nazarov,Muslinkin
, p. 1043 - 1047 (2007/10/03)
A procedure was developed for preparing chloromethylphosphonic dichloride, involving available raw materials and common process equipment. The optimal operation conditions were determined. This procedure can be used for production of chloromethylphosphonic dichloride both in laboratory and under industrial conditions.
