207407-50-9

Usage

Uses

Used in Organic Synthesis:
2,4,6-Heptatrienenitrile,7-(dimethylamino)-(9CI) is used as a key intermediate in organic synthesis for the production of various compounds. Its unique structure and reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,6-Heptatrienenitrile,7-(dimethylamino)-(9CI) is used as a building block for the development of new drugs. Its potential biological activity and compatibility with other chemical entities make it a promising candidate for the creation of novel therapeutic agents.
Used in Agrochemical Industry:
2,4,6-Heptatrienenitrile,7-(dimethylamino)-(9CI) is also utilized in the agrochemical industry as an intermediate for the synthesis of various agrochemicals. Its ability to form stable compounds with other molecules makes it suitable for the development of effective pesticides and other agricultural chemicals.
Used in Medicinal Research:
Due to its potential biological activity, 2,4,6-Heptatrienenitrile,7-(dimethylamino)-(9CI) is being studied for its medicinal properties. Researchers are exploring its interactions with biological systems to understand its therapeutic potential and develop new treatments for various diseases.

Upstream product

• 19816-96-7 tropone oxime tosylate 
• 4185-69-7 1-(2,4-dinitrophenyl)-pyridinium chloride 
• 4688-60-2 Zincke aldehyde 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 
• 118348-28-0 (2Z,4Z,6E)-7-Dimethylamino-hepta-2,4,6-trienenitrile 
• 118348-20-2 6-(dimethylamino)-(Z,Z,Z)-1,3,5-hexatrienecarbonitrile 
• 124-40-3 dimethyl amine 

Downstream Products

• 118348-28-0 (2Z,4Z,6E)-7-Dimethylamino-hepta-2,4,6-trienenitrile 

Relevant academic research and scientific papers

Synthesis of isotopically labelled L-phenylalanine and L-tyrosine

A synthetic route to stable-isotope-substituted L-phenylalanine is presented, which allows the introduction of 13C, 15N, and deuterium labels at any position or combination of positions. For labelling of the aromatic ring, a synthetic route to ethyl benzoate (or benzonitrile) has been developed, based on the electrocyclic ring-closure of a 1,6-disubstituted hexatriene system, with in situ aromatization by elimination of one (amino) substituent. Several important (highly isotopically enriched) synthons have been prepared, namely benzonitrile, benzaldehyde, ethyl benzoate, and ethyl diphenyloxyacetate. Labelled L-phenylalanines have been synthesized from both aromatic precursors by initial conversion into sodium phenylpyruvate and subsequent transformation of this intermediate into the L-α-amino acid by an enzymatic reductive amination reaction. In this manner, highly enriched phenylalanines are obtained on the 10-gram scale and with high enantiomeric purities (≥ 99% ee). The method has been validated by the synthesis of [1'13C]-L-Phe and [2-D]-L-Phe. In addition, two methods are described for the introduction of isotopes into L-tyrosine starting from the isotopically enriched precursors benzonitrile and ethyl benzoate.

A novel synthesis of trienes by nucleophilic ring cleavage of tropone oxime tosylate

In contrast to chemical reactions of troponoid ([7]annulenone) compounds reported so far, the tosylate of tropone oxime reveals a novel ring opening reaction under mild conditions at the temperature between -20 and 0 °C. This nucleophilic reaction affords

Highly Stereoselective Ring Opening Reaction of Tropone Oxime Tosylate with Nucleophiles

The tosylate (1) of tropone oxime undergoes a novel ring-opening reaction under mild conditions with secondary amines, alkoxides, and Grignard reagents affording stereoselectively 6-substituted (1Z,3Z,5Z)-hexa-1,3,5-triene-carbonitriles (2a-h) as sole pro