207500-64-9

Upstream product

• 35616-03-6 4-hydroxyphenyl 4-methyl-1-benzenesulfonate 
• 100-44-7 benzyl chloride 
• 103-16-2 4-Benzyloxyphenol 
• 98-59-9 p-toluenesulfonyl chloride 
• 2581-43-3 cyclohexane-1,4-diyl bis(4-methylbenzenesulfonate) 

Downstream Products

• 103-16-2 4-Benzyloxyphenol 
• 35616-03-6 4-hydroxyphenyl 4-methyl-1-benzenesulfonate 
• 54589-41-2 (4-(benzyloxy)phenyl)(phenyl)methanone 
• 834-25-3 4-methylphenyl benzyl ether 

Relevant academic research and scientific papers

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.

Instantaneous deprotection of tosylamides and esters with Sml 2/amine/water

(Chemical Equation Presented) Sml2/amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

Ether aryl sulfonic acid esters with improved antimalarial/anticancer activities

Our previous report showed that our current benchmark agent, 4-methoxyphenyl p-toluenesulibnate, is a selective antimalarial/anticancer agent. A series of related sulfones and sulfonic acid esters is now examined. 4-Allyloxyphenyl p-toluenesulfonate is a superior antimalarial/anticancer agent. 4-Methoxyphenyl 4-nitrobenzenesulfonate is a superior antimalarial agent, but shows poorer inhibition of human skin cancer cells. CSIRO 2006.