2076-91-7

Basic information

• Product Name: NSC 55712
• Synonyms: NSC 55712;TPT-260 (Dihydrochloride);TPT-260 (Dihydrochloride), NSC55712;TPT-260 2HCl;Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride;TPT-260 , NSC55712;NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride;TPT-260 Dihydrochloride, >=98%
• CAS NO: 2076-91-7
• Molecular Formula: C8H14Cl2N4S3
• Molecular Weight: 333.32456
• Product Categories: Inhibitors
• Mol File: 2076-91-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 210℃ (Decomposition)
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: NSC 55712(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 55712(2076-91-7)
• EPA Substance Registry System: NSC 55712(2076-91-7)

Safety Data

• Hazardous Substances Data: 2076-91-7(Hazardous Substances Data)

Usage

Uses

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]