207686-06-4

Upstream product

• 184844-11-9 (2R,3R)-3-((S)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-2-hydroxy-2,5-dimethyl-hexanoic acid methyl ester 
• 113543-30-9 (S)-4-benzyl-3-(4-methylpentanoyl)oxazolidin-2-one 
• 96136-31-1 (S)-2-amino-3-(4-methoxyphenyl)-N-methylpropionamide 

Downstream Products

• 207686-13-3 (2R,3R)-2-Hydroxy-3-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-2,5-dimethyl-hexanoic acid 

Relevant academic research and scientific papers

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Examination of the S1 area of the active site of pro-stromelysin has led us to the design of novel and potent inhibitors of matrix metalloproteinases containing constrained quaternary-hydroxy group at P1. The synthesis and biological activity of these compounds with variations at P1', P2', and P3' will be described.