20769-30-6

Upstream product

• 859781-99-0 4-acetoxy-1,2-bis-diacetoxymethyl-benzene 
• 6500-51-2 4-methoxybenzene-1,2-dicarbaldehyde 
• 99758-16-4 5-hydroxy-4,5-dihydroisobenzofuran 
• 54125-02-9 danishefsky's diene 
• 103410-75-9 4,4-diethoxy-but-2t-enal 
• 22618-23-1 3,4-dimethylphenyl acetate 
• 78119-72-9 acetate of α,α,α',α'-tetrabromo-3,4-xylenol 

Relevant academic research and scientific papers

An unusual synthesis of phthalaldehyde

A variety of oxidizing agents convert 5-hydroxy-4,5- dihydroisobenzofuran into phthalaldehyde. Other oxidizing agents produce both phthalaldehyde and its 4-hydroxy derivative.

Efficient synthesis of 4-substituted-ortho-phthalaldehyde analogues: Toward the emergence of new building blocks

4-Methoxy-ortho-phthalaldehyde and 4-hydroxy-ortho-phthalaldehyde are potentially useful molecules for fluorimetric analysis of a variety of amines and for the elaboration of complex molecular architectures. Nevertheless, literature generally describes their synthesis in very low yield (below 5%), mainly due to the inefficiency of the last oxidation step. In this paper, we report a reliable synthesis of 4-substituted-ortho-phthalaldehyde analogues in 51% overall yield owing to the addition of a protecting step of the unstable key intermediate 4,5-dihydroisobenzofuran-5-ol. Oxidation and deprotection steps were also studied in order to provide an effective availability of these two dialdehyde compounds that may increase their future applications.

Novel synthesis of a conformationally-constrained analog of DDATHF

A conformationally-constrained analog of DDATHF, in which the glutamate moiety is tied hack to the benzoyl ring through an isoindolinone ring, has been synthesized through a series of steps which commence with a Diels-Alder reaction of the Danishefsky die

Daisy chain assembly formed from a cucurbit[6]uril derivative

The building block synthesis of a derivative of CB[6] that bears a reactive propargyloxy group and its functionalization by click chemistry to yield 1 which contains a covalently attached isobutylammonium group is presented. Compound 1 undergoes self-assembly to yield a cyclic [c2] daisy chain assembly (12) in water. The behavior of 12 in response to various stimuli (e.g., guests and CB[n] receptors) is described.

HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS

This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.

Synthesis of Conformationally-Constrained Glutamate Analogues of the Antitumor Agents DDATHF, LY254155, and LY231514

Analogues of the active antitumor agents DDATHF (4), LY254155 (11), and LY231514 (14) have been prepared in which the rotational flexibility of the benzoylglutamate amide linkage is constrained by incorporation of a methylene bridge between the glutamate amide nitrogen and the ortho position of the aromatic ring. Evaluation of the resulting isoindolinones as in vitro inhibitors of the growth of CCRF-CEM cells revealed that, although some analogues retained activity, in no case was cytotoxicity enhanced, and in some cases it was substantially reduced.