6500-51-2

Basic information

• Product Name: 4-METHOXYPHTHALALDEHYDE
• Synonyms: 4-METHOXYPHTHALALDEHYDE
• CAS NO: 6500-51-2
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.16
• Mol File: 6500-51-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHOXYPHTHALALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYPHTHALALDEHYDE(6500-51-2)
• EPA Substance Registry System: 4-METHOXYPHTHALALDEHYDE(6500-51-2)

Safety Data

• Hazardous Substances Data: 6500-51-2(Hazardous Substances Data)

Upstream product

• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 28281-76-7 5-methoxyisobenzofuran-1,3-dione 
• 99758-16-4 5-hydroxy-4,5-dihydroisobenzofuran 
• 201230-82-2 carbon monoxide 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 586-38-9 3-Methoxybenzoic acid 
• 99-06-9 3-Carboxyphenol 
• 36132-95-3 (2-hydroxymethyl-5-methoxy-phenyl)-methanol 
• 379697-34-4 (2-bromo-5-methoxy-benzyloxy)-trimethyl-silane 
• 98015-07-7 2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal 
• 150192-39-5 2-Bromo-5-methoxybenzyl alcohol 
• 55414-72-7 (2-amino-5-methoxyphenyl)methanol 
• 98015-08-8 2-<2-(1,3-dioxalanyl)>-4-methoxybenzaldehyde 

Downstream Products

• 942229-73-4 C₂₅H₂₀O₃ 
• 1258512-41-2 2'-benzoyl-5-methoxy-1,2'-spirobi[indene]-1,3-dione 
• 1258512-20-7 (E)-2-(3-(4-chlorophenyl)-3-oxoprop-1-enyl)-4-methoxybenzaldehyde 
• 1333428-89-9 2-methoxy-6-nitronaphthalen-7-yl-methyl 2-(benzamido)acetate 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 20769-30-6 4-hydroxy-ortho-phthalaldehyde 
• 412041-55-5 ((4-methoxy-1,2-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) 

Relevant articles and documents

Site-Selective Functionalization of (sp3)C?H Bonds Catalyzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor

The selective functionalization of one C?H bond over others in nearly identical steric and electronic environments can facilitate the construction of complex molecules. We report site-selective functionalizations of C?H bonds, differentiated solely by rem

Enantioselective Iridium-Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes

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Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity and molecular mechanism(s) of action

Water-soluble isoindoloquinoxalin (IIQ) imines and the corresponding acetates were conveniently prepared from the key intermediates 2-(2′-aminophenyl)-2H-isoindole-1-carbonitriles obtained by a Strecker reaction between substituted 1,2-dicarbaldehydes and 1,2-phenylenediamines. Both series were screened by the National Cancer Institute (Bethesda, MD) and showed potent antiproliferative activity against a panel of 60 human tumor cell lines. Several of the novel compounds showed GI50 values at a nanomolar level on the majority of the tested cell lines. Among IIQ derivatives, methoxy substituents at positions 3 and 8 or/and 9 were especially effective in impairing cell cycle progression and inducing apoptosis in cancer cells. These effects were associated to IIQ-mediated impairment of tubulin polymerization at pharmacologically significant concentrations of tested compounds. In addition, impaired DNA topoisomerase I functions and perturbation in telomere architecture were observed in cells exposed to micromolar concentrations of IIQ derivatives. The above results suggest that IIQ derivatives exhibit multi-target cytotoxic activities.