20770-16-5Relevant articles and documents
NUCLEAR ISOPRENYLATION OF POLYHYDROXYACETHOPHENONES ACID CATALYSED CONDENSATION WITH ISOPRENE
Ahluwalia, V. K.,Arora, K. K.
, p. 1437 - 1440 (2007/10/02)
A novel method of nuclear isoprenylation leading to the exclusive formation of 2,2-dimethylchromans has been achieved by the direct condensation of polyhydroxyacetophenones with isoprene in presence of phosphoric acid.Acetylchromans, thus obtained, are dehydrogenated with DDQ to given corresponding 2,2-dimethylchromenes.Using this method, synthesis of number of naturally occuring chromenes, viz. ripariochromene A (6), eupatoriochromene (10), encecalin (11), isoevodionol (16), evodionol (17) and methylevodionol (18) has been affected.