20771-08-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenyl-oxazole-4-carbaldehyde is used as an active pharmaceutical ingredient for its potential applications in antiviral and antifungal medications, contributing to the development of new treatments for various diseases.
Used in Agrochemical Industry:
2-PHENYL-OXAZOLE-4-CARBALDEHYDE serves as a key component in the formulation of agrochemicals, aiding in the protection of crops from viral and fungal infections, thereby enhancing agricultural productivity.
Used in Organic Synthesis:
2-Phenyl-oxazole-4-carbaldehyde is utilized as a building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications.
Used in Biological Research:
It is employed as a fluorescent probe in biological systems, facilitating the study of various biological processes and interactions at the molecular level.
Used in Material Science:
2-Phenyl-oxazole-4-carbaldehyde has been investigated for its potential use in the development of new materials for optical and electronic devices, reflecting its versatility in contributing to technological advancements.

InChI:InChI=1/C10H7NO2/c12-6-9-7-13-10(11-9)8-4-2-1-3-5-8/h1-7H

Upstream product

• 1204-70-2 2-phenyl-1,3-oxazole-4-carbonyl chloride 
• 30494-97-4 4-chloromethyl-2-phenyl-oxazole 
• 59398-98-0 (2-phenyl-1,3-oxazol-4-yl)methanol 
• 855405-22-0 benzyl 2-phenyloxazole-4-carboxylate 
• 20771-04-4 (1S,2R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(2-phenyl-oxazol-4-yl)-2-ξ-propenyloxy-ethanol 
• 21737-05-3 {(Ξ)-1-[(2Ξ,4S)-4r-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5t-(2-phenyl-oxazol-4-yl)-[1,3]dioxolan-2-yl]-ethyl}-iodo-mercury 
• 6750-04-5 propargyl benzoate 
• 1816-88-2 2-azido-1-phenylethan-1-one 
• 70-11-1 α-bromoacetophenone 
• 36841-57-3 (5-bromo-2-phenyl-oxazol-4-yl)-methanol 
• 36841-52-8 5-bromo-4-chloromethyl-2-phenyl-oxazole 
• 20874-54-8 (1S,2R)-1-acetoxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-(2-phenyl-oxazol-4-yl)-2-propenyloxy-ethane 
• 55044-06-9 methyl 2-phenyl-2-oxazoline-4-carboxylate 
• 20989-42-8 N-benzoylserine methyl ester 

Downstream Products

• 104396-32-9 4-(2-nitro-propenyl)-2-phenyl-oxazole 
• 3156-55-6 4-(2-nitro-vinyl)-2-phenyl-oxazole 
• 99970-09-9 3-(2-phenyl-oxazol-4-yl)-acrylic acid 
• 50704-29-5 2-Benzamido-3-dimethylaminoacrolein 
• 125549-26-0 5-{4-[3-(2-Phenyl-oxazol-4-yl)-propionyl]-benzyl}-thiazolidine-2,4-dione 
• 100063-43-2 3-(2-phenyl-oxazol-4-yl)-propionic acid 
• 41711-23-3 N-(1,3-dioxopropan-2-yl)benzamide 

Relevant academic research and scientific papers

O-Transfer-facilitated cyclizations of propargylamides with TMSN3: Selective synthesis of tetrazoles and dihydroimidazoles

An unprecedented formal [3+2] annulation of propargylamides with TMSN3 to deliver functionalized tetrazoles is developed. Oxygen-atom transfer (OAT) from the amide group to the CC bond was realized via a NIS-triggered-cyclization/ring-opening cascade pathway. The OAT process enables the amide to serve as a two-atom unit in the reactions. Notably, in situ umpolung of azide occurred when terminal propargylamides were employed in this reaction, providing an array of diiodomethylated dihydroimidazoles.

Thermal rearrangement of azido ketones into oxazoles via azirines: One-pot, metal-free heteroannulation to functionalized 1,3-oxazoles

α-Azidoacetophenones were converted into 2-aryl-1,3-oxazole-4- carbaldehydes through rearrangement of the carbon framework upon exposure to DMF/POCl3. The unprecedented rearrangement occurs via alkenyl azides and 2H-azirines. A mechanism for this unusual reaction was proposed and evidenced.

A flexible synthetic approach to the hennoxazoles

Three advanced intermediates corresponding to the carbon skeleton of the hennoxazoles have been prepared. Central to the strategy is the synthesis of the oxazoles prior to coupling with the other fragments and a dithiane addition to allow for the generati