59398-98-0

Basic information

• Product Name: (2-PHENYL-OXAZOL-4-YL)-METHANOL
• Synonyms: (2-PHENYL-OXAZOL-4-YL)-METHANOL
• CAS NO: 59398-98-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• EINECS: 604-604-1
• Mol File: 59398-98-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2-PHENYL-OXAZOL-4-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-PHENYL-OXAZOL-4-YL)-METHANOL(59398-98-0)
• EPA Substance Registry System: (2-PHENYL-OXAZOL-4-YL)-METHANOL(59398-98-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 59398-98-0(Hazardous Substances Data)

Usage

General Description

(2-Phenyl-oxazol-4-yl)-methanol, also known as 2-Phenyl-4-oxazol-5-yl-methanol, is a chemical compound with the molecular formula C10H9NO2. It is a white solid with a melting point of around 129-131 degrees Celsius. (2-PHENYL-OXAZOL-4-YL)-METHANOL is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the research and development of new medications. Additionally, it has potential applications in the field of organic chemistry and may be used as a building block for the synthesis of other organic compounds. However, it is important to handle this compound with care, as it may pose health risks if not used properly.

Upstream product

• 1204-70-2 2-phenyl-1,3-oxazole-4-carbonyl chloride 
• 100-52-7 benzaldehyde 
• 6704-31-0 oxetan-3-one 
• 55-21-0 benzamide 
• 55044-06-9 methyl 2-phenyl-2-oxazoline-4-carboxylate 
• 20989-42-8 N-benzoylserine methyl ester 
• 59171-72-1 2-phenyl-oxazole-4-carboxylic acid methyl ester 
• 23012-16-0 2-phenyl-1,3-oxazole-4-carboxylic acid 
• 36841-57-3 (5-bromo-2-phenyl-oxazol-4-yl)-methanol 
• 53872-19-8 4-carbomethoxy-5-methoxy-2-phenyl-1,3-oxazole 
• 39819-39-1 2-phenyl-oxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 30494-98-5 2-(2-phenyloxazol-4-yl)acetonitrile 
• 100723-29-3 2,2'-(2-phenyl-oxazol-4-ylmethylazanediyl)-bis-ethanol 
• 101938-56-1 4-(2-phenyl-oxazol-4-ylmethyl)-morpholine 
• 109671-06-9 1-ethyl-1-(2-phenyl-oxazol-4-ylmethyl)-piperidinium; bromide 
• 694503-62-3 methyl (E)-4-(4-{[5-(tert-butyldiphenylsilyloxymethyl)-2-phenyl-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-4-phenylbutanoate 
• 441356-84-9 4-(methoxymethoxymethyl)-2-phenyl-1,3-oxazole 
• 99073-82-2 4-bromomethyl-2-phenyl-oxazole 
• 20771-08-8 2-phenyl-1,3-oxazole-4-carbaldehyde 
• 36841-57-3 (5-bromo-2-phenyl-oxazol-4-yl)-methanol 
• 30494-97-4 4-chloromethyl-2-phenyl-oxazole 

Relevant articles and documents

Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB

A high-throughput screening effort on 45,000 compounds resulted in the discovery of a disubstituted oxazole as a new structural class inhibitor of Mycobacterium tuberculosis (Mtb). In order to improve the activity and investigate the SAR of this scaffold, a series of disubstituted azole analogues have been designed and synthesized. The newly synthesized compounds 1a-y were evaluated for their in vitro anti-TB activity versus replicating, multi- and extensive drug resistant Mtb strains. All the compounds, except 1o, 1p and 1q, showed potent anti-TB activity with MIC of 1-64 mg/L. The test of broad spectrum panel revealed that this series are specific to Mtb. The cytotoxicity assessment indicated that the compounds were not cytotoxic against HEK 293 cells. The compounds could have a novel mechanism to anti-Mtb as they can inhibit drug sensitive and drug resistant Mtb.

A flexible synthetic approach to the hennoxazoles

Three advanced intermediates corresponding to the carbon skeleton of the hennoxazoles have been prepared. Central to the strategy is the synthesis of the oxazoles prior to coupling with the other fragments and a dithiane addition to allow for the generati

Sommelet reaction with 2 aryl 4 chlormethyl oxazoles

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