20772-70-7

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 62-53-3 aniline 

Downstream Products

• 84819-29-4 N-phenyl-2-(aminomethyl)-4-methoxyphenol 
• 132120-41-3 6-Methoxy-3-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine 
• 84821-31-8 Cu(CH₃OC₆H₃(O)CHNC₆H₅)2 
• 1227260-64-1 6-methoxy-N-phenyl-3,3a,4,9a-tetrahydro-2H-furo[2,3-b]chromene-4-amine 
• 1227260-77-6 7-methoxy-N-phenyl-2,3,4,4a,5,10a-hexahydropyrano[2,3-b]chromene-4-amine 
• 1322617-93-5 N-(3-benzyl-6-methoxy-2-oxo-4-(phenylamino)chroman-3-yl)benzamide 
• 1322617-95-7 N-(3-benzyl-6-methoxy-2-oxo-4-(phenylamino)chroman-3-yl)benzamide 
• 1360873-59-1 (3aS,4R,9aR)-6-methoxy-N-phenyl-3,3a,4,9a-tetrahydro-2H-furo[2,3-b]chromen-4-amine 

Relevant academic research and scientific papers

Copper-Catalyzed Asymmetric Annulation Reactions of Carbenes with 2-Iminyl- or 2-Acyl-Substituted Phenols: Convenient Access to Enantioenriched 2,3-Dihydrobenzofurans

We have developed a method for the highly diastereo- and enantioselective construction of 2,3-dihydrobenzofurans bearing tetrasubstituted carbon stereocenters by means of annulation reactions between carbenes and 2-iminyl- or 2-acyl-substituted phenols through catalysis by readily accessible copper(I)/bisoxazoline catalysts under mild conditions. These reactions feature a unique mechanism in which the copper catalyst serves a dual function: first it reacts with the diazo compound to generate a metal carbene, and second, upon formation of an oxonium ylide, it acts as a Lewis acid to activate the imine or ketone for diastereo- and enantioselective cyclization.

Carbocation Organocatalysis in Interrupted Povarov Reactions to cis-Fused Pyrano- and Furanobenzodihydropyrans

Tritylium cation-catalyzed interrupted Povarov reactions afforded cis-4-aminobenzodihydropyrans in excellent yields (90 %) within 10 min by low catalyst loadings (1 mol-%). A mechanism involving Lewis acidic catalysis by a carbocation was proposed and val

Sulfonic acid supported on hydroxyapatite-encapsulated-γ-Fe 2O3 nanocrystallites as a magnetically separable catalyst for one-pot reductive amination of carbonyl compounds

A novel, environmentally friendly procedure has been developed for the preparation of secondary or tertiary amines by one-pot reductive amination of carbonyl compounds using sodium borohydride in the presence of a magnetically recoverable sulfonic acid supported on hydroxyapatite-encapsulated-γ- Fe2O3 [γ-Fe2O3@HAP-SO 3H] at room temperature. The catalyst was easily separated from the reaction mixture by applying an external magnet and reused for six cycles without significant loss of catalytic activity.

Catalytic asymmetric mannich-ketalization reaction: Highly enantioselective synthesis of aminobenzopyrans

"Chemical Equation Present" Domino catalysis: We have developed the first enantioselective domino Mannich-ketalization reaction of o-hydroxy benzaldimines with electron-rich alkenes (see scheme). The new reaction sequence provides an easy and direct acces

Qualitative analysis of the stability of the oxazine ring of various benzoxazine and pyridooxazine derivatives with proton nuclear magnetic resonance spectroscopy

A series of 3,4-dihydro-1,3-benzoxazine and 3,4-dihydro-1,3-pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.

Antioxidant-Based Inhibitors of Leukotriene Biosynthesis. The Discovery of 6--1-propen-3-yl>-2,3-dihydro-5-benzofuranol, a Potent Topical Antiinflammatory Agent

The leukotrienes, metabolites of arachidonic acid produced through the action of the enzyme 5-lipoxygenase, are important mediators of immediate hypersensitivity and inflammation.Among the variety of diseases in which the leukotrienes may play a symptomat