20778-47-6

Basic information

• Product Name: 1,1-CYCLOPROPANEDIACETONITRILE
• Synonyms: 1,1-CYCLOPROPANEDIACETONITRILE;2,2'-(Cyclopropane-1,1-diyl)diacetonitrile
• CAS NO: 20778-47-6
• Molecular Formula: C7H8N2
• Molecular Weight: 120.15
• Mol File: 20778-47-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 298 ºC
• Flash Point: 149 ºC
• Appearance: /
• Density: 1.057
• Vapor Pressure: 0.00132mmHg at 25°C
• Refractive Index: 1.4578
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,1-CYCLOPROPANEDIACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-CYCLOPROPANEDIACETONITRILE(20778-47-6)
• EPA Substance Registry System: 1,1-CYCLOPROPANEDIACETONITRILE(20778-47-6)

Safety Data

• Hazardous Substances Data: 20778-47-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C7H8N2/c8-5-3-7(1-2-7)4-6-9/h1-4H2

Upstream product

• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 29086-41-7 1,1-bis(bromomethyl)cyclopropane 
• 151-50-8 potassium cyanide 
• 6202-96-6 1,1-bis-chloromethyl-cyclopropane 
• 22308-08-3 cyclopropane-1,1-diyldimethanediyl bis(4-methylbenzenesulfonate) 
• 143-33-9 sodium cyanide 
• 83321-23-7 1,1-bis(iodomethyl)cyclopropane 
• 136476-38-5 cyclopropane-1,1-diylbis(methylene) dimethanesulfonate 
• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 

Downstream Products

• 1194-45-2 6-azaspiro[2.5]octane-5,7-dione 
• 893411-52-4 spiro[2.5]octane-5,7-dione 
• 1037834-62-0 6-azaspiro-[2.5]-octane hydrochloride 
• 1377186-70-3 C₇H₁₂N₂*ClH 
• 214479-60-4 5-ethoxy-6-aza-spiro[2.5]oct-5-ene 
• 70197-77-2 (1-carboxymethylcyclopropyl)acetic acid 

Relevant articles and documents

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R). Previously, we designed and synthesized structural mimics of 5-oxo-ETE such as 1 using an indole scaffold. In the present work, we added various substituents at C-3 of this moiety to block potential β-oxidation of the 5-oxo-valerate side chain, and investigated the structure-activity relationships of the resulting novel β-oxidation-resistant antagonists. Cyclopropyl and cyclobutyl substituents were well tolerated in this position, but were less potent as the highly active 3S-methyl compound. It seems likely that 3-alkyl substituents can affect the conformation of the 5-oxovalerate side chain containing the critical keto and carboxyl groups, thereby affecting interaction with the OXE-receptor.

ORTHO-SUBSTITUTED HALOALKYLSULFONANILIDE DERIVATIVE AND HERBICIDE

Novel herbicides are provided. A haloalkylsulfonanilide derivative represented by the formula (1) or an agrochemically acceptable salt thereof: the formula (1): wherein A is -C(R7)(R8)- or -N(R9)-, W is an oxygen atom or a sulfur atom, n is an integer of from 1 to 4, R1 is halo C1 -C6 alkyl, R2 is a hydrogen atom, C1 - C6 alkyl or the like, each of R3 and R4 is independently a hydrogen atom, C1 - C6 alkyl or the like, each of R5, R6, R7 and R8 is independently a hydrogen atom, a halogen, C1 - C6 alkyl or the like, R9 is a hydrogen atom, C1 - C6 alkyl or the like, and X is halogen, C1 - C6 alkyl or the like.