70197-77-2

Basic information

• Product Name: 1,1-Cyclopropanediacetic acid
• Synonyms: 1,1-Cyclopropanediacetic acid;2,2'-(cyclopropane-1,1-diyl)diaceticacid
• CAS NO: 70197-77-2
• Molecular Formula: C7H10O4
• Molecular Weight: 158.1519
• Mol File: 70197-77-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 105 °C
• Boiling Point: 383.5±15.0 °C(Predicted)
• Appearance: /
• Density: 1.362±0.06 g/cm3(Predicted)
• PKA: 4.46±0.10(Predicted)
• CAS DataBase Reference: 1,1-Cyclopropanediacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Cyclopropanediacetic acid(70197-77-2)
• EPA Substance Registry System: 1,1-Cyclopropanediacetic acid(70197-77-2)

Safety Data

• Hazardous Substances Data: 70197-77-2(Hazardous Substances Data)

Usage

General Description

1,1-Cyclopropanediacetic acid is a chemical compound with the molecular formula C6H8O4. It is a cyclic compound containing a cyclopropane ring and two carboxylic acid groups. It is mainly used as a building block in organic synthesis and pharmaceutical research. 1,1-Cyclopropanediacetic acid has potential applications in the development of new drugs and agrochemicals. Its unique cyclic structure and functional groups make it a valuable reagent in the preparation of various pharmaceutical intermediates. Due to its high reactivity and distinct structure, 1,1-Cyclopropanediacetic acid offers great versatility in the formation of diverse compounds with potential biological and pharmaceutical activities.

Upstream product

• 598-10-7 cyclopropane-1,1-dicarboxylic acid 
• 1531624-01-7 dimethyl 2,2′-(cyclopropane-1,1-diyl)diacetate 
• 83321-23-7 1,1-bis(iodomethyl)cyclopropane 
• 136476-38-5 cyclopropane-1,1-diylbis(methylene) dimethanesulfonate 
• 22308-08-3 cyclopropane-1,1-diyldimethanediyl bis(4-methylbenzenesulfonate) 
• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 
• 20778-47-6 (1-cyanomethyl-cyclopropyl)-acetonitrile 

Downstream Products

• 1194-45-2 6-azaspiro[2.5]octane-5,7-dione 
• 893411-52-4 spiro[2.5]octane-5,7-dione 

Relevant articles and documents

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R). Previously, we designed and synthesized structural mimics of 5-oxo-ETE such as 1 using an indole scaffold. In the present work, we added various substituents at C-3 of this moiety to block potential β-oxidation of the 5-oxo-valerate side chain, and investigated the structure-activity relationships of the resulting novel β-oxidation-resistant antagonists. Cyclopropyl and cyclobutyl substituents were well tolerated in this position, but were less potent as the highly active 3S-methyl compound. It seems likely that 3-alkyl substituents can affect the conformation of the 5-oxovalerate side chain containing the critical keto and carboxyl groups, thereby affecting interaction with the OXE-receptor.

Process for preparing spiro[2.5]octane-5,7-dione

Disclosed is a method for the synthesis of spiro[2.5]octane-5,7-dione useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed are novel intermediates used in the synthesis of this compound.

ORTHO-SUBSTITUTED HALOALKYLSULFONANILIDE DERIVATIVE AND HERBICIDE

Novel herbicides are provided. A haloalkylsulfonanilide derivative represented by the formula (1) or an agrochemically acceptable salt thereof: the formula (1): wherein A is -C(R7)(R8)- or -N(R9)-, W is an oxygen atom or a sulfur atom, n is an integer of from 1 to 4, R1 is halo C1 -C6 alkyl, R2 is a hydrogen atom, C1 - C6 alkyl or the like, each of R3 and R4 is independently a hydrogen atom, C1 - C6 alkyl or the like, each of R5, R6, R7 and R8 is independently a hydrogen atom, a halogen, C1 - C6 alkyl or the like, R9 is a hydrogen atom, C1 - C6 alkyl or the like, and X is halogen, C1 - C6 alkyl or the like.