207798-38-7Relevant articles and documents
8-substituted styryl xanthine derivative and application thereof
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, (2021/02/10)
The invention discloses an 8-substituted styryl xanthine derivative and application thereof, and particularly relates to a novel 8-substituted styryl xanthine derivative and a pharmaceutical composition containing the compound which can be used as a selective adenosine A2A receptor antagonist. The invention also relates to a method for preparing the compound and the pharmaceutical composition, andapplication of the compound and the pharmaceutical composition in preparation of drugs for treating adenosine A2A receptor related diseases, especially Parkinson's disease.
Tetrahydroquinoline derivative as well as preparation method and application thereof
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Paragraph 0099; 0105-0107, (2020/12/31)
The invention belongs to the field of drug synthesis, and provides a tetrahydroquinoline derivative shown as a general formula (I) and pharmaceutically acceptable salt, stereoisomers or prodrugs thereof, in which A, Ra, Rb, n, m and R are as described in
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship
Vianello, Paola,Sartori, Luca,Amigoni, Federica,Cappa, Anna,Fagá, Giovanni,Fattori, Raimondo,Legnaghi, Elena,Ciossani, Giuseppe,Mattevi, Andrea,Meroni, Giuseppe,Moretti, Loris,Cecatiello, Valentina,Pasqualato, Sebastiano,Romussi, Alessia,Thaler, Florian,Trifiró, Paolo,Villa, Manuela,Botrugno, Oronza A.,Dessanti, Paola,Minucci, Saverio,Vultaggio, Stefania,Zagarrí, Elisa,Varasi, Mario,Mercurio, Ciro
supporting information, p. 1693 - 1715 (2017/03/20)
The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1). KDM1A is overexpressed in several tumor types, thus representing an emerging target for the development of novel cancer therapeutics. We have previously describe