207798-71-8

Basic information

• Product Name: 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[4-(pyridin-4-yl)benzoyl]piperazine
• Synonyms: 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[4-(pyridin-4-yl)benzoyl]piperazine
• CAS NO: 207798-71-8
• Molecular Weight: 491.998
• Mol File: 207798-71-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[4-(pyridin-4-yl)benzoyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[4-(pyridin-4-yl)benzoyl]piperazine(207798-71-8)
• EPA Substance Registry System: 1-[(6-chloronaphthalen-2-yl)sulfonyl]-4-[4-(pyridin-4-yl)benzoyl]piperazine(207798-71-8)

Safety Data

• Hazardous Substances Data: 207798-71-8(Hazardous Substances Data)

Upstream product

• 4385-76-6 4-(4-pyridinyl)benzoic acid 
• 203521-17-9 1-[(6-chloronaphthalen-2-yl]sulfonyl]piperazine 
• 102878-14-8 6-chloro-2-naphthalenesulphonic acid 
• 91-58-7 2-chloronaphthalene 
• 222986-36-9 1-(tert-butoxycarbonyl)-4-[4-(4-pyridyl)benzoyl]piperazine 
• 102153-63-9 6-chloronaphth-2-ylsulfonyl chloride 

Downstream Products

• 222984-88-5 4-[4-[[4-[(6-Chloronaphthalen-2-yl)sulfonyl]piperazin-1-yl]carbonyl]phenyl]-1-methylpyridinium iodide 
• 216957-20-9 4-[4-[[4-[(6-Chloronaphthalen-2-yl)sulfonyl]piperazin-1-yl]carbonyl]phenyl]pyridine N-oxide 

Relevant articles and documents

Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites

Compound 7 was identified as the active metabolite of 6 by HPLC and mass spectral analysis. Modification of lead compound 7 by transformation of its N-oxide 6-6 biaryl ring system and fused aromatics produced a series of non-basic fXa inhibitors with excellent potency in anti-fXa and anticoagulant assays. The optimized compounds 73b and 75b showed sub to one digit micromolar anticoagulant activity (PTCT2). Particularly, anti-fXa activity was detected in plasma of rats orally administered with 1 mg/kg of compound 75b.