20781-86-6

Upstream product

• 593-71-5 Chloroiodomethane 
• 28178-42-9 2,6-diisopropylphenyl isocyanate 
• 24544-04-5 2,6-diisopropylbenzenamine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 116855-48-2 2-(diethylamino)-N-<2,6-bis(1-methylethyl)phenyl>acetamide 
• 909030-52-0 2-azido-N-(2',6'-diisopropylphenyl)acetamide 
• 1129865-64-0 N-(2,6-diisopropylphenyl)-2-(2,4-dioxo-1-phenyl-1,3-diazaspiro[4.4]non-3-yl)acetamide 
• 1129865-68-4 N-(2,6-diisopropylphenyl)-2-(4-oxo-1-phenyl-1,3-diazaspiro[4.5]dec-3-yl)-acetamide 
• 1128305-31-6 N-(2,6-diisopropylphenyl)-2-[(1-phenylaminocyclohexylmethyl)amino]-acetamide 
• 1128305-36-1 N-(2,6-diisopropylphenyl)-2-(2,2-dioxo-1-phenyl-2λ6-thia-1,3-diaza-spiro[4.5]dec-3-yl)acetamide 
• 1240785-05-0 2-(8-acetyl-2,4-dioxo-1-p-tolyl-1,3,8-triazaspiro[4.5]dec-3-yl)-N-(2,6-diisopropylphenyl)-acetamide 
• 1240874-36-5 N-(2,6-diisopropylphenyl)-2-(2,4-dioxo-1-pyridin-3-yl-1,3-diazaspiro[4.5]dec-3-yl)acetamide 
• 1256379-59-5 1-[N-(2,6-diisopropylphenyl)-2-acetamido]-3,5-dimethylpyrazole 

Relevant academic research and scientific papers

Versatile Bulky N,N′,N′-Substituted 1,2-Ethanediamine Ligands and Their Lithium, Aluminium, and Gallium Derivatives

Sterically demanding N,N′,N′-substituted 1,2-ethanediamine ligands have been prepared from commercially available starting materials by applying a facile one-step procedure. These ligands offer advantages compared to known systems: a suppressed delocalization due to the saturated backbone inhibits a noninnocent behaviour and the low symmetry of the related metal complexes makes them potential candidates for asymmetric catalysis. The ligands are readily transformed into the corresponding lithium derivatives 4, which in turn act as starting materials to access the corresponding aluminium and gallium dichlorides 5 and 6, respectively. In addition, deprotonation by Al(CH3)3gives rise to the related dimethylalane 7. All main-group element compounds have been studied by means of single X-ray crystallography and spectroscopic methods.

Homologation of isocyanates with lithium carbenoids: A straightforward access to α-halomethyl- and α,α-dihalomethylamides

Treatment of widely available isocyanates with monohalolithium and dihalolithium carbenoids provides a valuable protocol for the one-pot preparation of α-halo- and α,α-dihaloacetamide derivatives. While monohalolithium carbenoids can be prepared by a smoo

Addition of lithium carbenoids to isocyanates: A direct access to synthetically useful N-substituted 2-haloacetamides

The addition of lithium carbenoids to isocyanates provides a versatile access to N-substituted 2-haloacetamides: the reaction tolerates the presence of variously functionalized substituents on the nitrogen atom, including sterically demanding ones and reactive halogens. No erosion of the enantiopurity was observed in the case of optically active isocyanates. One of the substrates prepared has been employed in Charette's type chemoselective addition of a Grignard reagent to access an α-chloroketone.

Highly selective ruthenium metathesis catalysts for ethenolysis

N-Aryl,N-alkyl N-heterocyclic carbene (NHC) ruthenium metathesis catalysts are highly selective toward the ethenolysis of methyl oleate, giving selectivity as high as 95% for the kinetic ethenolysis products over the thermodynamic self-metathesis products. The examples described herein represent some of the most selective NHC-based ruthenium catalysts for ethenolysis reactions to date. Furthermore, many of these catalysts show unusual preference and stability toward propagation as a methylidene species and provide good yields and turnover numbers at relatively low catalyst loading (500 ppm). A catalyst comparison showed that ruthenium complexes bearing sterically hindered NHC substituents afforded greater selectivity and stability and exhibited longer catalyst lifetime during reactions. Comparative analysis of the catalyst preference for kinetic versus thermodynamic product formation was achieved via evaluation of their steady-state conversion in the cross-metathesis reaction of terminal olefins. These results coincided with the observed ethenolysis selectivities, in which the more selective catalysts reach a steady state characterized by lower conversion to cross-metathesis products compared to less selective catalysts, which show higher conversion to cross-metathesis products.

NOVEL N-PHENYLACETAMIDE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

The present invention relates to novel compounds of general formula (I) : and to cosmetic and pharmaceutical compositions containing such a compound.

N-PHENYLACETAMIDE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1 AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

The present invention relates to novel compounds of general Formula (I), and also to cosmetic and pharmaceutical compositions containing such a compound.

NOVEL DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

The present invention relates to novel compounds of general formula (I) and also to cosmetic and pharmaceutical compositions containing such a compound.

NOVEL DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

The present invention relates to SOAT-1 inhibitors of general formula (I): and also to cosmetic and pharmaceutical compositions containing such a compound.

DERIVATIVES OF N-PHENYLACETAMIDE, INHIBITORS OF THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM

The present invention relates to compounds of Formula (I) : as well as the cosmetic and pharmaceutical compositions containing such a compound.

DERIVATIVES OF N-PHENYLACETAMIDE AS INHIBITORS OF THE ENZYME SOAT1 FOR PHARMACEUTICAL AND COSMETIC USE

The present invention relates to compounds of Formula (I): as well as the cosmetic and pharmaceutical compositions containing such a compound.