207910-92-7

Basic information

• Product Name: (Z)-3-(4-bromophenyl)-2-hydroxyacrylic acid
• Synonyms: (Z)-3-(4-bromophenyl)-2-hydroxyacrylic acid
• CAS NO: 207910-92-7
• Molecular Weight: 243.057
• Mol File: 207910-92-7.mol

Chemical Properties

• CAS DataBase Reference: (Z)-3-(4-bromophenyl)-2-hydroxyacrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(4-bromophenyl)-2-hydroxyacrylic acid(207910-92-7)
• EPA Substance Registry System: (Z)-3-(4-bromophenyl)-2-hydroxyacrylic acid(207910-92-7)

Safety Data

• Hazardous Substances Data: 207910-92-7(Hazardous Substances Data)

Upstream product

• 186605-19-6 4-(4-bromophenyl)methylene-2-methyl-5(4H)-oxazolone 
• 1122-91-4 4-bromo-benzaldehyde 
• 1273258-11-9 (Z)-4-(4-bromobenzylidene)-2-methyloxazol-5(4H)-one 

Downstream Products

• 1357447-93-8 (Z)-3-(4-bromophenyl)-2-methoxy-N-phenylacrylamide 
• 1357447-94-9 (Z)-3-(4-bromophenyl)-N-(4-fluorophenyl)-2-methoxyacrylamide 
• 1357447-95-0 (Z)-3-(4-bromophenyl)-N-(4-chlorophenyl)-2-methoxyacrylamide 
• 52217-01-3 (Z)-3-(4-bromophenyl)-2-methoxyacrylic acid 
• 62561-74-4 (2R)-2-amino-3-(4-bromophenyl)propanoic acid 

Relevant articles and documents

An Atropos Biphenyl Bisphosphine Ligand with 2,2′-tert-Butylmethylphosphino Groups for the Rhodium-Catalyzed Asymmetric Hydrogenation of Enol Esters

This is an update of our previous work concerning the development of Atropos biphenyl bisphosphine ligands. An unexpected Atropos structural property was confirmed by single crystal X-ray diffraction and this result is consistent with the computational calculations described in our previous work. This P-stereogenic bisphosphine ligand possessing a biphenyl backbone and 2,2′-tert-butylmethylphosphino groups has been applied to the Rh-catalyzed asymmetric hydrogenation of enol esters, which has not been widely studied and can be used for the synthesis of several important bioactive compounds. Although there is room for further improvement in enantioselectivity, the results reported herein provide a further understanding of such types of ligands. (Figure presented.).

5-(α-Halobenzyl)- and 5-Benzylidene-2,2-dimethyl-1,3-oxazolidin-4-ones in Synthesis of α-Hydroxy Acids

The reactions of acid hydrolysis of 5-(α-halobenzyl)- and 5-benzylidene-2,2-dimethyl-1,3-oxazolidin-4-ones were studied. A possibility of the synthesis of corresponding α-hydroxy acids was shown.

Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase

A practical and efficient biocatalytic synthesis of aromatic d-amino acids has been developed, based on the reductive amination of the corresponding α-keto acids via a recombinant whole cell system composed of an engineered dehydrogenase and cofactor recycling apparatus. The reaction was shown to give excellent enantioselectivity (≥98%) and good yields at the preparative scale across a broad range of substrates. Additionally, the structure of the variant enzyme was solved to allow rationalisation of the observed reaction rates. The engineered whole cell catalyst was also used to mediate the production of d-phenylalanine derivatives from racemic mixtures and cheaper l-amino acids by combining it with an enantiocomplementary deaminase. (Figure presented.).

ANTIDIABETIC ENOLIC GLUCOSIDE OF PHENYLPYRUVIC ACID

PROBLEM TO BE SOLVED: To provide an antidiabetic enolic glucoside of phenylpyruvic acid and derivatives thereof, for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pr

Synthesis of novel cinnamanilides as potential immunosuppressive agents

A series of new cinnamanilides (6-40) were synthesized and their immunosuppressive activity and cytotoxicity were evaluated. Most of the cinnamanilides showed good immunosuppressive activity. Among the synthesized compounds, (Z)-N-(4-bromophenyl)-2-methox