207926-27-0Relevant articles and documents
Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides
Xu, Dan,Liu, Zhihua,Tang, Weijun,Xu, Lijin,Hyder, Zeynab,Xiao, Jianliang
body text, p. 6104 - 6107 (2009/04/04)
A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.
Synthesis of Functionalized 3-Pyridyl Methyl Ketones
Wright,Hageman,McClure
, p. 717 - 723 (2007/10/03)
A synthesis of 3-pyridyl methyl ketones is described that employs a palladium-catalyzed olefination of 3-bromopyridines with butyl vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether in situ. This method has been applied to bromoquinoline substrates as well. The reaction is compatible with a variety of functional groups.